5jxl

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==Cryo-EM structure of the flagellar hook of Campylobacter jejuni==
==Cryo-EM structure of the flagellar hook of Campylobacter jejuni==
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<StructureSection load='5jxl' size='340' side='right' caption='[[5jxl]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<SX load='5jxl' size='340' side='right' viewer='molstar' caption='[[5jxl]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jxl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_81116 Campylobacter jejuni subsp. jejuni 81116]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JXL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_81116 Campylobacter jejuni subsp. jejuni 81116]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JXL FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxl OCA], [http://pdbe.org/5jxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jxl RCSB], [http://www.ebi.ac.uk/pdbsum/5jxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxl ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxl OCA], [https://pdbe.org/5jxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jxl RCSB], [https://www.ebi.ac.uk/pdbsum/5jxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxl ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A1L1QK18_CAMJ8 A0A1L1QK18_CAMJ8]
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The bacterial flagellar hook is a tubular helical structure made by the polymerization of multiple copies of a protein, FlgE. Here we report the structure of the hook from Campylobacter jejuni by cryo-electron microscopy at a resolution of 3.5 A. On the basis of this structure, we show that the hook is stabilized by intricate inter-molecular interactions between FlgE molecules. Extra domains in FlgE, found only in Campylobacter and in related bacteria, bring more stability and robustness to the hook. Functional experiments suggest that Campylobacter requires an unusually strong hook to swim without its flagella being torn off. This structure reveals details of the quaternary organization of the hook that consists of 11 protofilaments. Previous study of the flagellar filament of Campylobacter by electron microscopy showed its quaternary structure made of seven protofilaments. Therefore, this study puts in evidence the difference between the quaternary structures of a bacterial filament and its hook.
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Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions.,Matsunami H, Barker CS, Yoon YH, Wolf M, Samatey FA Nat Commun. 2016 Nov 4;7:13425. doi: 10.1038/ncomms13425. PMID:27811912<ref>PMID:27811912</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5jxl" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Flagellar protein 3D structures|Flagellar protein 3D structures]]
*[[The Bacterial Flagellar Hook|The Bacterial Flagellar Hook]]
*[[The Bacterial Flagellar Hook|The Bacterial Flagellar Hook]]
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*[[User:Fadel A. Samatey/FlgE III/Intrinsically Disordered Flagellar Rod Stretch|User:Fadel A. Samatey/FlgE III/Intrinsically Disordered Flagellar Rod Stretch]]
 
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== References ==
 
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<references/>
 
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Campylobacter jejuni subsp. jejuni 81116]]
[[Category: Campylobacter jejuni subsp. jejuni 81116]]
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[[Category: Matsunami, H]]
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[[Category: Large Structures]]
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[[Category: Samatey, F A]]
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[[Category: Matsunami H]]
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[[Category: Wolf, M]]
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[[Category: Samatey FA]]
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[[Category: Campylobacter jejuni]]
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[[Category: Wolf M]]
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[[Category: Flagellar hook]]
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[[Category: Helical assembly of flge]]
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[[Category: Motor protein]]
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Current revision

Cryo-EM structure of the flagellar hook of Campylobacter jejuni

5jxl, resolution 3.50Å

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