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1dfj

From Proteopedia

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[[Image:1dfj.jpg|left|200px]]
 
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{{Structure
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==RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A==
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|PDB= 1dfj |SIZE=350|CAPTION= <scene name='initialview01'>1dfj</scene>, resolution 2.5&Aring;
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<StructureSection load='1dfj' size='340' side='right'caption='[[1dfj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene>
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<table><tr><td colspan='2'>[[1dfj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The September 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ribonuclease A'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_9 10.2210/rcsb_pdb/mom_2008_9]. The November 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DFJ FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dfj OCA], [https://pdbe.org/1dfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dfj RCSB], [https://www.ebi.ac.uk/pdbsum/1dfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dfj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/1dfj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dfj ConSurf].
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<div style="clear:both"></div>
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'''RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A'''
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==See Also==
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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*[[Ribonuclease inhibitor|Ribonuclease inhibitor]]
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==Overview==
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== References ==
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The leucine-rich repeat is a recently characterized structural motif used in molecular recognition processes as diverse as signal transduction, cell adhesion, cell development, DNA repair and RNA processing. We present here the crystal structure at 2.5 A resolution of the complex between ribonuclease A and ribonuclease inhibitor, a protein built entirely of leucine-rich repeats. The unusual non-globular structure of ribonuclease inhibitor, its solvent-exposed parallel beta-sheet and the conformational flexibility of the structure are used in the interaction; they appear to be the principal reasons for the effectiveness of leucine-rich repeats as protein-binding motifs. The structure can serve as a model for the interactions of other proteins containing leucine-rich repeats with their ligands.
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1DFJ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFJ OCA].
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==Reference==
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A structural basis of the interactions between leucine-rich repeats and protein ligands., Kobe B, Deisenhofer J, Nature. 1995 Mar 9;374(6518):183-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7877692 7877692]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Pancreatic ribonuclease]]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Ribonuclease A]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Deisenhofer, J.]]
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[[Category: Toll-like Receptors]]
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[[Category: Kobe, B.]]
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[[Category: Deisenhofer J]]
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[[Category: ACE]]
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[[Category: Kobe B]]
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[[Category: SO4]]
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[[Category: complex (ribonuclease/inhibitor)]]
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[[Category: hydrolase]]
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[[Category: leucine-rich repeat]]
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[[Category: ribonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:37:43 2008''
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Current revision

RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A

PDB ID 1dfj

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