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3krd

From Proteopedia

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{{Seed}}
 
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[[Image:3krd.jpg|left|200px]]
 
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<!--
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==Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with Fellutamide B==
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The line below this paragraph, containing "STRUCTURE_3krd", creates the "Structure Box" on the page.
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<StructureSection load='3krd' size='340' side='right'caption='[[3krd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3krd]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KRD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEB:N~2~-[(3R)-3-HYDROXYDODECANOYL]-L-ASPARAGINYL-N~1~-[(1S)-1-(HYDROXYMETHYL)-3-METHYLBUTYL]-L-GLUTAMAMIDE'>FEB</scene></td></tr>
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{{STRUCTURE_3krd| PDB=3krd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3krd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3krd OCA], [https://pdbe.org/3krd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3krd RCSB], [https://www.ebi.ac.uk/pdbsum/3krd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3krd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSA_MYCTU PSA_MYCTU] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kr/3krd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3krd ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with Fellutamide B===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_20558127}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20558127 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20558127}}
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==About this Structure==
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3KRD is a 28 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KRD OCA].
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==Reference==
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<ref group="xtra">PMID:20558127</ref><references group="xtra"/>
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Li D]]
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[[Category: Li, D.]]
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[[Category: Li H]]
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[[Category: Li, H.]]
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[[Category: Autocatalytic cleavage]]
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[[Category: Binding site]]
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[[Category: Fellutamide b]]
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[[Category: Hydrolase]]
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[[Category: Inhibition]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Protease]]
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[[Category: Proteasome]]
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[[Category: Protein subunit]]
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[[Category: Substrate specificity]]
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[[Category: Threonine protease]]
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[[Category: Virulence]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:14:23 2010''
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Current revision

Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with Fellutamide B

PDB ID 3krd

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