Nonstructural protein

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[[Image:3o9s.jpg|left|200px|thumb|Crystal Structure of Nonstructural protein dimer [[3o9s]]]]
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<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'>
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{{STRUCTURE_3o9s| PDB=3o9s | SIZE=400| SCENE= |right|CAPTION=Nonstructural protein dimer [[3o9s]] }}
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__TOC__
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[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see<br />
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*[[User:Michael Strong/H1N1/NS]]<br />
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*[[User:Michael Strong/H1N1/NS1/MSA]]<br />
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*[[User:Michael Strong/H1N1/NS2/MSA]]<br />
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*[[Student Project 4 for UMass Chemistry 423 Spring 2015]].
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For NS1 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP1]].<br />
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For NS2 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP2]].<br />
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For NS3 of SARS-CoV-2 see [[SARS-CoV-2 enzyme Papain-like]].<br />
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For NS4 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP4]].<br />
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For NS6 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP6]].<br />
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For NS7 or '''replicase polyprotein 1ab light chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP7]].<br />
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For NS8 or '''replicase polyprotein 1ab heavy chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP8]].<br />
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For NS9 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP9]].<br />
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For NS10 or '''replicase polyprotein 1ab''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP10]].<br />
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For NS12 of SARS-CoV-2 see also [[Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi]].<br />
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For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see [[SARS-CoV-2 enzyme RdRp]].<br />
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SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called '''replication-transcription complex'''.<br />
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For NS16+NS10 of SARS-CoV-2 see [[SARS-CoV-2 enzyme 2'-O-MT]].
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== Relevance ==
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The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease. See [[Bailey Dove/Victrelis]].
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== Structural highlights ==
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<scene name='46/461364/Cv/4'>Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions</scene><ref>PMID:12509436</ref>.
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[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle. The images at the left and at the right correspond to one representative NS, ''i.e.'' the crystal structure of Nonstructural protein from Influenza virus ([[3o9s]]). For homology model and multiple sequence alignment see [[User:Michael Strong/H1N1/NS]], [[User:Michael Strong/H1N1/NS1/MSA]] and [[User:Michael Strong/H1N1/NS2/MSA]].
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{{TOC limit|limit=2}}
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<br />
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== 3D Structures of Nonstructural protein ==
== 3D Structures of Nonstructural protein ==
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[[Nonstructural protein 3D structures]]
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''Updated June 2012''
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</StructureSection>
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[[3o9q]] – IvNS1 (mutant) – Influenza virus<br />
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[[3o9r]], [[3o9s]], [[3o9t]], [[3o9u]], [[3f5t]] – IvNS1<br />
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[[3m8a]], [[2z0a]], [[1xeq]], [[1ail]] – IvNS1 RNA-binding domain<br />
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[[3p31]] – IvNS1 C terminal effector domain<br />
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[[3p38]], [[3p39]] – IvNS1 C terminal effector domain (mutant)<br />
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[[1ns1]] - IvNS1 RNA-binding domain - NMR<br />
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[[3m5r]], [[2gx9]] - IvNS1 effector domain<br />
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[[1pd3]] – IvNS2 M1-binding domain<br />
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[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dentue virus<br />
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[[2o1j]] – RvNSP4 diarrhea-inducing domain – Rotavirus<br />
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[[2gu0]] – RvNS2<br />
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[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
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[[1fw5]] – NSP1 membrane-binding domain – Semliki forest virus – NMR<br />
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[[1qol]] – NSP20A (mutant) - Foot-and-mouth disease virus<br />
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[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br />
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[[2gdt]], [[2hsx]] – SvNS1 (mutant) – Sars coronavirus – NMR<br />
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[[2jzd]], [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br />
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[[2kaf]] - SvNS3 residues 1473-1532 – NMR <br />
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[[2kys]] – SvNS7 – NMR<br />
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[[2l8k]] – NS7 residues 1454-1575 – NMR<br />
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[[3mtv]] – NS1 residues 181-383 – PRRS virus
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===Nonstructural protein binary complex===
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[[2xbm]] – DvNS5 methyltransferase domain + RNA<br />
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[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br />
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[[2b5l]] - SvNSV + DNA damage-binding protein<br />
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[[1nhv]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br />
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[[1dxp]], [[1dy8]], [[1dy9]] – HvNS4A + HvHelicase NS3<br />
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[[3phe]] – HvNS5B + quinolone derivative<br />
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[[3ub0]] – NSP6 + NSP7 – Feline infectious peritonitis virus
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu)

Drag the structure with the mouse to rotate

References

  1. ↑ Zhu Z, Shi Z, Yan W, Wei J, Shao D, Deng X, Wang S, Li B, Tong G, Ma Z. Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One. 2013;8(2):e55920. doi: 10.1371/journal.pone.0055920. Epub 2013 Feb 6. PMID:23405236 doi:http://dx.doi.org/10.1371/journal.pone.0055920
  2. ↑ Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14;278(11):9489-95. Epub 2002 Dec 30. PMID:12509436 doi:10.1074/jbc.M209397200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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