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2bei

From Proteopedia

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[[Image:2bei.jpg|left|200px]]
 
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{{Structure
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==X-ray structure of thialysine n-acetyltransferase (SSAT2) from homo sapiens==
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|PDB= 2bei |SIZE=350|CAPTION= <scene name='initialview01'>2bei</scene>, resolution 1.842&Aring;
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<StructureSection load='2bei' size='340' side='right'caption='[[2bei]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2bei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEI FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.842&#8491;</td></tr>
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|GENE= SAT2, SSAT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1246 ArgA], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00583 Acetyltransf_1]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bei OCA], [https://pdbe.org/2bei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bei RCSB], [https://www.ebi.ac.uk/pdbsum/2bei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bei ProSAT], [https://www.topsan.org/Proteins/CESG/2bei TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bei OCA], [http://www.ebi.ac.uk/pdbsum/2bei PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bei RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/SAT2_HUMAN SAT2_HUMAN] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bei_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bei ConSurf].
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<div style="clear:both"></div>
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'''X-ray structure of thialysine n-acetyltransferase (SSAT2) from homo sapiens'''
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==See Also==
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*[[Spermidine/spermine N-acetyltransferase|Spermidine/spermine N-acetyltransferase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2BEI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEI OCA].
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==Reference==
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Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A., Han BW, Bingman CA, Wesenberg GE, Phillips GN Jr, Proteins. 2006 Jul 1;64(1):288-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16596569 16596569]
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[[Category: Diamine N-acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bae, E.]]
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[[Category: Bae E]]
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[[Category: Bingman, C A.]]
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[[Category: Bingman CA]]
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[[Category: Bitto, E.]]
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[[Category: Bitto E]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Han BW]]
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[[Category: Han, B W.]]
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[[Category: Phillips Jr GN]]
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[[Category: Jr., G N.Phillips.]]
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[[Category: Wesenberg GE]]
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[[Category: Wesenberg, G E.]]
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[[Category: aah11751]]
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[[Category: bc011751]]
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[[Category: center for eukaryotic structural genomic]]
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[[Category: cesg]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: ssat2]]
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[[Category: structural genomic]]
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[[Category: thialysine n-acetyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:05:15 2008''
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Current revision

X-ray structure of thialysine n-acetyltransferase (SSAT2) from homo sapiens

PDB ID 2bei

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