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Chaperonin, Sandbox transition test

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[[Image:1pcq.png|left|200px|thumb|Crystal Structure of Chaperonin, [[1pcq]]]]
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==Your Heading Here (maybe something like 'Structure')==
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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This is a default text for your page '''Sandbox transition test'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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<StructureSection load='1pcq' size='350' side='right' caption='GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry [[1pcq]])' scene='Chaperonin/Groel_groes_comnplex/1'>
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== Function ==
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'''Chaperonins''' (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see [http://en.wikipedia.org/wiki/Chaperonins Chaperonins in Wikipedia].
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== Disease ==
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<br>
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Load 1eve and save with standard defaults - no reload standard display YES YES transition <scene name='10/1050327/Sb_transition_default/1'>Default</scene>
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<br>
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blow up
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always reload YES YES <scene name='10/1050327/Sb_transition_default/2'>default blow up</scene>
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<br>
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no reload YES YES <scene name='10/1050327/Sb_transition_default/3'>NO Reload Blow up</scene>
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== Relevance ==
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The most characterized CPN are in the GroEL/GroES complex from ''Escherichia coli'' and CPN60/CPN10 from ''Thermus thermophilus''. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya.
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== Structural highlights ==
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See also [[Chaperones]].
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</StructureSection>
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== 3D Structures of Chaperonin ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/13'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/7'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/5'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/8'>indirectly via solvent molecules</scene>.
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{{#tree:id=OrganizedByTopic|openlevels=0|
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<br>
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*'''Group I'''
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</StructureSection>
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*''Large subunit''
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**[[3m6c]] – MtGroEL1 apical domain – ''Mycobacterium tuberculosis''<BR />
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**[[1sjp]], [[3rtk]] – MtGroEL2 residues 42-539<BR />
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**[[3fbh]], [[2eu1]], [[1j4z]], [[1kpo]], [[1oel]], [[1grl]], [[2yey]] – EcGroEL (mutant) - ''Escherichia coli''<BR />
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**[[3e76]], [[2nwc]], [[1xck]], [[1ss8]], [[4hel]] – EcGroEL<BR />
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**[[3c9v]], [[3cau]], [[2ynj]] – EcGroEL – Cryo EM<BR />
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**[[2c7e]], [[1gr5]], [[4aaq]] - EcGroEL (mutant) – Cryo EM<BR />
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**[[1dk7]], [[1la1]] - EcGroEL apical domain<br />
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**[[1fy9]], [[1fya]], [[1kid]], [[1jon]], [[3vz6]], [[3vz7]], [[3vz8]] – EcGroEL apical domain (mutant) <BR />
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**[[1srv]] – TtCPN60 apical domain - ''Thermus thermophilus''<BR />
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**[[3osx]] - CPN60 apical domain – ''Xenorhabdus nematophila''<br />
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**[[1iok]] – CPN60 – ''Paracoccus denitrificans''
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*''Large subunit binary complex''
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**[[1kp8]] - EcGroEL (mutant) + ATP<BR />
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**[[4aar]], [[4aas]], [[4aau]], [[4ab2]], [[4ab3]] - EcGroEL (mutant) + ATP – Cryo EM<br />
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**[[1sx3]] - EcGroEL + ATP<BR />
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**[[1sx4]] - EcGroEL + ADP<BR />
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**[[4ki8]] - EcGroEL (mutant) + ADP<br />
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**[[1mnf]] – EcGroEL + polypeptide<BR />
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**[[2cgt]] – EcGroEL + capsid assbly protein GP31 – EM<BR />
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**[[1dkd]] - EcGroEL apical domain + polypeptide
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*''Small subunit''
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**[[3nx6]] – GroES residues 40-134 (mutant) – ''Xanthomonas oryzae''<BR />
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**[[1wnr]] – TtCPN10 residues 1-94<BR />
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**[[1p3h]], [[1hx5]] – MtCPN10<BR />
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**[[1p82]], [[1p83]] - MtCPN10 residues 1-25 - NMR<BR />
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**[[1egs]] - GroES residues 19-27 - NMR
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*''Large + small subunit''
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**[[1svt]], [[1pcq]] - EcGroEL + GroES<BR />
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**[[1pf9]], [[1aon]], [[4pko]] - EcGroEL + GroES + ADP<BR />
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**[[3wvl]] - EcGroEL (mutant) + GroES + ATP<br />
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**[[2c7c]], [[2c7d]] - EcGroEL + GroES – Cryo EM<BR />
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**[[1gru]] - EcGroEL + GroES + ATP + ADP – Cryo EM<BR />
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**[[3zpz]], [[3zq0]], [[3zq1]] - EcGroEL + GroES + ADP – Cryo EM<br />
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**[[1we3]] – TtCPN60 + CPN10<BR />
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**[[1wf4]], [[4v4o]], [[4pkn]] - TtCPN60 + CPN10 + ADP
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*'''Group II'''
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**[[3izh]], [[3izi]], [[3izj]], [[3izk]], [[3izl]], [[3izm]], [[3izn]], [[3los]], [[3iyf]], [[3j3x]] – MmCPN – ''Methanococcus maripaludis'' – EM<BR />
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**[[3kfb]], [[3kfe]], [[3kfk]] – MmCPN<BR />
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**[[3j02]], [[3j03]] – MmCPN (mutant) – Cryo EM<br />
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**[[3ruq]] - MmCPN + ADP<br />
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**[[3rus]] - MmCPN (mutant) + ADP<br />
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**[[3ruw]] - MmCPN (mutant) + ADP-AlF3<br />
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**[[3ruv]] - MmCPN (mutant) + ATP analog<br />
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*'''CCT'''
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**[[2xsm]], [[4b2t]] – bCPN CCT – bovine<BR />
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**[[3p9d]], [[3p9e]], [[4d8q]], [[4d8r]], [[4aol]], [[4apk]] – CPN CCT - yeast<br />
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**[[3iyg]], [[4a0o]] - bCPN CCT – Cryo EM<BR />
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**[[4a0v]] - bCPN CCT + AMPPNP – Cryo EM<br />
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**[[4a0w]] - bCPN CCT + ADP + AlF3 – Cryo EM<br />
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**[[4a13]] - bCPN CCT + ADP – Cryo EM<br />
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**[[3ktt]] - bCPN CCT β subunit – Cryo EM<BR />
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**[[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse
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*'''Hsp33'''
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See [[Heat Shock Proteins]]
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*'''Thermosome'''
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**[[1a6d]] - TaTherm α+β subunits – ''Thermoplasma acidophilum''<BR />
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**[[1a6e]] - TaTherm α+β subunits + ADP<BR />
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**[[1ass]], [[1asx]] - TaTherm α apical domain<BR />
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**[[1e0r]] – TaTherm β apical domain<br />
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**[[3ko1]] – AtTherm α subunit– ''Acidianus tengchongensis''<br />
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**[[3j1b]], [[3j1c]], [[3j1e]] - AtTherm α subunit – Cryo EM <br />
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**[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br />
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**[[3aq1]] – Therm – ''Methanococcoides burtonii''<br />
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**[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – ''Thermococcus KS-1''<br />
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**[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br />
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**[[1q3s]] - TkTherm α subunit (mutant) + ADP<br />
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**[[1lep]] – CPN-10 – ''Mycobacterium leprae''
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}}
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== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]
 

Revision as of 10:35, 8 March 2026

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Caption for this structure

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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