6r0j
From Proteopedia
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==The N-terminal domain of rhomboid protease YqgP== | ==The N-terminal domain of rhomboid protease YqgP== | ||
- | <StructureSection load='6r0j' size='340' side='right'caption='[[6r0j | + | <StructureSection load='6r0j' size='340' side='right'caption='[[6r0j]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6r0j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R0J FirstGlance]. <br> |
- | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r0j OCA], [https://pdbe.org/6r0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r0j RCSB], [https://www.ebi.ac.uk/pdbsum/6r0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r0j ProSAT]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/GLUP_BACSU GLUP_BACSU] Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter.<ref>PMID:15050034</ref> <ref>PMID:15616571</ref> <ref>PMID:15684070</ref> <ref>PMID:16621838</ref> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Magnesium homeostasis is essential for life and depends on magnesium transporters, whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom, but their functions are largely elusive. Using proteomics, we find that Bacillus subtilis rhomboid protease YqgP interacts with the membrane-bound ATP-dependent processive metalloprotease FtsH and cleaves MgtE, the major high-affinity magnesium transporter in B. subtilis. MgtE cleavage by YqgP is potentiated in conditions of low magnesium and high manganese or zinc, thereby protecting B. subtilis from Mn(2+) /Zn(2+) toxicity. The N-terminal cytosolic domain of YqgP binds Mn(2+) and Zn(2+) ions and facilitates MgtE cleavage. Independently of its intrinsic protease activity, YqgP acts as a substrate adaptor for FtsH, a function that is necessary for degradation of MgtE. YqgP thus unites protease and pseudoprotease function, hinting at the evolutionary origin of rhomboid pseudoproteases such as Derlins that are intimately involved in eukaryotic ER-associated degradation (ERAD). Conceptually, the YqgP-FtsH system we describe here is analogous to a primordial form of "ERAD" in bacteria and exemplifies an ancestral function of rhomboid-superfamily proteins. | ||
+ | |||
+ | Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease.,Began J, Cordier B, Brezinova J, Delisle J, Hexnerova R, Srb P, Rampirova P, Kozisek M, Baudet M, Coute Y, Galinier A, Veverka V, Doan T, Strisovsky K EMBO J. 2020 Jan 13:e102935. doi: 10.15252/embj.2019102935. PMID:31930742<ref>PMID:31930742</ref> | ||
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+ | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
+ | </div> | ||
+ | <div class="pdbe-citations 6r0j" style="background-color:#fffaf0;"></div> | ||
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+ | ==See Also== | ||
+ | *[[Rhomboid protease|Rhomboid protease]] | ||
+ | == References == | ||
+ | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
+ | [[Category: Bacillus subtilis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Began | + | [[Category: Began J]] |
- | [[Category: Strisovsky | + | [[Category: Strisovsky K]] |
- | [[Category: Veverka | + | [[Category: Veverka V]] |
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Current revision
The N-terminal domain of rhomboid protease YqgP
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