6r1h

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'''Unreleased structure'''
 
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The entry 6r1h is ON HOLD until Paper Publication
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==Crystal structure of the LRR ectodomain of the receptor kinase SOBIR1 from Arabidopsis thaliana.==
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<StructureSection load='6r1h' size='340' side='right'caption='[[6r1h]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6r1h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R1H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r1h OCA], [https://pdbe.org/6r1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r1h RCSB], [https://www.ebi.ac.uk/pdbsum/6r1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r1h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SBIR1_ARATH SBIR1_ARATH] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Acting as a counterplayer of BIR1, promotes the activation of plant defense and cell death (PubMed:19616764). Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity (PubMed:27251392). Functions as an inhibitor/regulator of abscission, probably by regulating membrane trafficking during abscission (PubMed:20081191).<ref>PMID:19616764</ref> <ref>PMID:20081191</ref> <ref>PMID:27251392</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Plant-unique membrane receptor kinases with leucine-rich repeat (LRR) extracellular domains are key regulators of development and immune responses. Here, the 1.55 A resolution crystal structure of the immune receptor kinase SOBIR1 from Arabidopsis is presented. The ectodomain structure reveals the presence of five LRRs sandwiched between noncanonical capping domains. The disulfide-bond-stabilized N-terminal cap harbours an unusual beta-hairpin structure. The C-terminal cap features a highly positively charged linear motif which was found to be largely disordered in this structure. Size-exclusion chromatography and right-angle light-scattering experiments suggest that SOBIR1 is a monomer in solution. The protruding beta-hairpin, a set of highly conserved basic residues at the inner surface of the SOBIR LRR domain and the presence of a genetic missense allele in LRR2 together suggest that the SOBIR1 ectodomain may mediate protein-protein interaction in plant immune signalling.
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Authors: Hohmann, U., Hothorn, M.
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Crystal structure of the leucine-rich repeat ectodomain of the plant immune receptor kinase SOBIR1.,Hohmann U, Hothorn M Acta Crystallogr D Struct Biol. 2019 May 1;75(Pt 5):488-497. doi:, 10.1107/S2059798319005291. Epub 2019 Apr 29. PMID:31063151<ref>PMID:31063151</ref>
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Description: Crystal structure of the LRR ectodomain of the receptor kinase SOBIR1 from Arabidopsis thaliana.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Hohmann, U]]
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<div class="pdbe-citations 6r1h" style="background-color:#fffaf0;"></div>
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[[Category: Hothorn, M]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
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[[Category: Hohmann U]]
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[[Category: Hothorn M]]

Current revision

Crystal structure of the LRR ectodomain of the receptor kinase SOBIR1 from Arabidopsis thaliana.

PDB ID 6r1h

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