8xag

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "8xag" [edit=sysop:move=sysop])
Current revision (06:16, 4 December 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8xag is ON HOLD
+
==Crystal structure of the chromodomain of Arabidopsis LHP1 in complex with histone H3.3K27me3 peptide==
-
 
+
<StructureSection load='8xag' size='340' side='right'caption='[[8xag]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8xag]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XAG FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xag OCA], [https://pdbe.org/8xag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xag RCSB], [https://www.ebi.ac.uk/pdbsum/8xag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xag ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LHP1_ARATH LHP1_ARATH] Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Transcriptional repressor that binds DNA on GAGA-like motif and 5'-(A/G/T)AACCCTA(A/G)-3' consensus motif in the promoters of target genes. Recognizes and binds histone H3 tails methylated at 'Lys-27' (H3K27me) but depleted in active histone marks such as H3K4me, leading to epigenetic repression. When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes (PubMed:27495811).<ref>PMID:11731464</ref> <ref>PMID:12826620</ref> <ref>PMID:15356387</ref> <ref>PMID:16549797</ref> <ref>PMID:16682972</ref> <ref>PMID:19097900</ref> <ref>PMID:27495811</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arabidopsis thaliana]]
 +
[[Category: Large Structures]]
 +
[[Category: Huang Y]]
 +
[[Category: Liu Y]]

Current revision

Crystal structure of the chromodomain of Arabidopsis LHP1 in complex with histone H3.3K27me3 peptide

PDB ID 8xag

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8xag"
Personal tools