DNA repair protein

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<StructureSection load='2qsg' size='350' side='right' caption='Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry [[2qsg]])' scene='78/780971/Cv/1'>
<StructureSection load='2qsg' size='350' side='right' caption='Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry [[2qsg]])' scene='78/780971/Cv/1'>
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__TOC__
== Function ==
== Function ==
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'''DNA repair protein Rad4''' is a yeast protein involved in DNA damage recognition in nucleotide excision repair<ref>PMID:15916602</ref>. Rad4 is an ortholog of the XPC protein. Rad4 opens up damaged DNA by inserting β-hairpin into the duplex and flipping out two damage-containing nucleotide pairs<ref>PMID:27035942</ref>.
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'''DNA repair proteins''' correct DNA damage caused by mutations or toxins<ref>PMID:7773744</ref>.
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*'''DNA repair protein Rad4''' is a yeast protein involved in DNA damage recognition in nucleotide excision repair<ref>PMID:15916602</ref>. Rad4 is an ortholog of the XPC protein. Rad4 opens up damaged DNA by inserting β-hairpin into the duplex and flipping out two damage-containing nucleotide pairs<ref>PMID:27035942</ref>.
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*'''DNA repair protein Rev1''' is a DNA polymerase active in DNA damage sites. It contains 2 ubiquitin-binding sites<ref>PMID:29778604</ref>.
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*'''DNA repair protein Rad23A, DNA repair protein Rad23B''' see [[UV excision repair protein]].
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*'''DNA repair protein Rad51''' is a multifunctional protein with a role in DNA replication, homologous recombination repair and immunity<ref>PMID:28334891</ref>.
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*'''DNA repair protein RadA''' see [[Resolvase]].
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*'''DNA repair protein Xrcc1''' interacts with components of single-strand DNA breaks repair in mammalian cells<ref>PMID:31324530</ref>.
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*'''DNA repair protein Xrcc4''' interacts with components of double-strand DNA breaks repair in mammalian cells<ref>PMID:9259561</ref>.
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*'''DNA repair protein PprA''' or '''Pleiotropic protein promoting DNA repair A''' facilitates the radiation resistance of ''Deinococcus radiodurans''<ref>PMID:30481062</ref>.
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== Relevance ==
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'''DNA repair protein Rad51''' is a potential marker for DNA repair in solid malignancies<ref>PMID:28477336</ref>.
== Disease ==
== Disease ==
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Mutations in the nucleotide excision repair pathway can cause the xeroderma pigmentosum skin cancer predisposition syndrome<ref>PMID:17882165</ref>.
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Mutations in '''DNA repair protein Rad4''' can cause the xeroderma pigmentosum skin cancer predisposition syndrome<ref>PMID:17882165</ref>.
== Structural highlights ==
== Structural highlights ==
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<scene name='78/780971/Cv/2'>Structure of yeast Rad4 complex with Rad23 and DNA</scene> (PDB entry [[2qsg]]). Rad4 β-hairpin inserts into DNA making hydrogen bond interactions as well as non-bonding interactions with it<ref>PMID:17882165</ref>.
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<scene name='78/780971/Cv/2'>Structure of yeast Rad4 complex with Rad23 and DNA</scene> (PDB entry [[2qsg]]). <scene name='78/780971/Cv/3'>Rad4 β-hairpin</scene> inserts into DNA making hydrogen bond interactions as well as non-bonding interactions with it<ref>PMID:17882165</ref>. <scene name='78/780971/Cv/4'>Residues which interact with DNA are shown as sticks and labled</scene>.
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</StructureSection>
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== 3D Structures of DNA repair protein Rad4 ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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== 3D Structures of DNA repair protein ==
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[[DNA repair protein 3D structures]]
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[[2qsf]] – yRad4 + Rad23 - yeast<br />
 
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[[2qsg]], [[2qsh]], [[4yir]], [[6cfi]] – yRad4 + Rad23 + DNA <br />
 
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[[2m14]] – yRad4 internal UBA domain + RNA polymerase II TFB1 - NMR<br />
 
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[[4bu0]], [[4bu1]], [[6hm3]], [[6hm4]] – fyRad4 BRCT1 domain + phosphopeptide – fission yeast<br />
 
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[[4bmc]] – fyRad4 BRCT1 + BRCT2 domains <br />
 
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[[4bmd]] – fyRad4 BRCT3 + BRCT4 domains <br />
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry 2qsg)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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