DNA repair protein
From Proteopedia
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<StructureSection load='2qsg' size='350' side='right' caption='Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry [[2qsg]])' scene='78/780971/Cv/1'> | <StructureSection load='2qsg' size='350' side='right' caption='Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry [[2qsg]])' scene='78/780971/Cv/1'> | ||
| + | __TOC__ | ||
== Function == | == Function == | ||
| - | '''DNA repair protein Rad4''' is a yeast protein involved in DNA damage recognition in nucleotide excision repair<ref>PMID:15916602</ref>. Rad4 is an ortholog of the XPC protein. Rad4 opens up damaged DNA by inserting β-hairpin into the duplex and flipping out two damage-containing nucleotide pairs<ref>PMID:27035942</ref>. | + | '''DNA repair proteins''' correct DNA damage caused by mutations or toxins<ref>PMID:7773744</ref>. |
| + | *'''DNA repair protein Rad4''' is a yeast protein involved in DNA damage recognition in nucleotide excision repair<ref>PMID:15916602</ref>. Rad4 is an ortholog of the XPC protein. Rad4 opens up damaged DNA by inserting β-hairpin into the duplex and flipping out two damage-containing nucleotide pairs<ref>PMID:27035942</ref>. | ||
| + | *'''DNA repair protein Rev1''' is a DNA polymerase active in DNA damage sites. It contains 2 ubiquitin-binding sites<ref>PMID:29778604</ref>. | ||
| + | *'''DNA repair protein Rad23A, DNA repair protein Rad23B''' see [[UV excision repair protein]]. | ||
| + | *'''DNA repair protein Rad51''' is a multifunctional protein with a role in DNA replication, homologous recombination repair and immunity<ref>PMID:28334891</ref>. | ||
| + | *'''DNA repair protein RadA''' see [[Resolvase]]. | ||
| + | *'''DNA repair protein Xrcc1''' interacts with components of single-strand DNA breaks repair in mammalian cells<ref>PMID:31324530</ref>. | ||
| + | *'''DNA repair protein Xrcc4''' interacts with components of double-strand DNA breaks repair in mammalian cells<ref>PMID:9259561</ref>. | ||
| + | *'''DNA repair protein PprA''' or '''Pleiotropic protein promoting DNA repair A''' facilitates the radiation resistance of ''Deinococcus radiodurans''<ref>PMID:30481062</ref>. | ||
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| + | == Relevance == | ||
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| + | '''DNA repair protein Rad51''' is a potential marker for DNA repair in solid malignancies<ref>PMID:28477336</ref>. | ||
== Disease == | == Disease == | ||
| - | Mutations in | + | Mutations in '''DNA repair protein Rad4''' can cause the xeroderma pigmentosum skin cancer predisposition syndrome<ref>PMID:17882165</ref>. |
== Structural highlights == | == Structural highlights == | ||
<scene name='78/780971/Cv/2'>Structure of yeast Rad4 complex with Rad23 and DNA</scene> (PDB entry [[2qsg]]). <scene name='78/780971/Cv/3'>Rad4 β-hairpin</scene> inserts into DNA making hydrogen bond interactions as well as non-bonding interactions with it<ref>PMID:17882165</ref>. <scene name='78/780971/Cv/4'>Residues which interact with DNA are shown as sticks and labled</scene>. | <scene name='78/780971/Cv/2'>Structure of yeast Rad4 complex with Rad23 and DNA</scene> (PDB entry [[2qsg]]). <scene name='78/780971/Cv/3'>Rad4 β-hairpin</scene> inserts into DNA making hydrogen bond interactions as well as non-bonding interactions with it<ref>PMID:17882165</ref>. <scene name='78/780971/Cv/4'>Residues which interact with DNA are shown as sticks and labled</scene>. | ||
| - | </StructureSection> | ||
| - | == 3D Structures of DNA repair protein Rad4 == | ||
| - | + | == 3D Structures of DNA repair protein == | |
| + | [[DNA repair protein 3D structures]] | ||
| - | [[2qsf]] – yRad4 + Rad23 - yeast<br /> | ||
| - | [[2qsg]], [[2qsh]], [[4yir]], [[6cfi]], [[6ubf]], [[6ug1]], [[6uin]] – yRad4 + Rad23 + DNA <br /> | ||
| - | [[7k04]] – yRad4 + Rad23 + Rad33 + TFIIH + DNA – Cryo EM<br /> | ||
| - | [[7m2u]] – yRad4 + Rad23 + Rad25 + Rad33 + TFIIH + DNA – Cryo EM<br /> | ||
| - | [[2m14]] – yRad4 internal UBA domain + RNA polymerase II TFB1 - NMR<br /> | ||
| - | [[4bu0]], [[4bu1]], [[6hm3]], [[6hm4]] – fyRad4 BRCT1 domain + phosphopeptide – fission yeast<br /> | ||
| - | [[4bmc]] – fyRad4 BRCT1 + BRCT2 domains <br /> | ||
| - | [[4bmd]] – fyRad4 BRCT3 + BRCT4 domains <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
