DNA repair protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:50, 4 May 2025) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
<StructureSection load='2qsg' size='350' side='right' caption='Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry [[2qsg]])' scene='78/780971/Cv/1'>
<StructureSection load='2qsg' size='350' side='right' caption='Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry [[2qsg]])' scene='78/780971/Cv/1'>
 +
__TOC__
 +
== Function ==
 +
'''DNA repair proteins''' correct DNA damage caused by mutations or toxins<ref>PMID:7773744</ref>.
 +
*'''DNA repair protein Rad4''' is a yeast protein involved in DNA damage recognition in nucleotide excision repair<ref>PMID:15916602</ref>. Rad4 is an ortholog of the XPC protein. Rad4 opens up damaged DNA by inserting β-hairpin into the duplex and flipping out two damage-containing nucleotide pairs<ref>PMID:27035942</ref>.
 +
*'''DNA repair protein Rev1''' is a DNA polymerase active in DNA damage sites. It contains 2 ubiquitin-binding sites<ref>PMID:29778604</ref>.
 +
*'''DNA repair protein Rad23A, DNA repair protein Rad23B''' see [[UV excision repair protein]].
 +
*'''DNA repair protein Rad51''' is a multifunctional protein with a role in DNA replication, homologous recombination repair and immunity<ref>PMID:28334891</ref>.
 +
*'''DNA repair protein RadA''' see [[Resolvase]].
 +
*'''DNA repair protein Xrcc1''' interacts with components of single-strand DNA breaks repair in mammalian cells<ref>PMID:31324530</ref>.
 +
*'''DNA repair protein Xrcc4''' interacts with components of double-strand DNA breaks repair in mammalian cells<ref>PMID:9259561</ref>.
 +
*'''DNA repair protein PprA''' or '''Pleiotropic protein promoting DNA repair A''' facilitates the radiation resistance of ''Deinococcus radiodurans''<ref>PMID:30481062</ref>.
 +
== Relevance ==
-
 
+
'''DNA repair protein Rad51''' is a potential marker for DNA repair in solid malignancies<ref>PMID:28477336</ref>.
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
-
== Function ==
+
-
 
+
-
'''DNA repair protein Rad4''' is a yeast protein involved in DNA damage recognition in nucleotide excision repair<ref>PMID:15916602</ref>. Rad4 is an ortholog of the XPC protein. Rad4 opens up damaged DNA by inserting β-hairpin into the duplex and flipping out two damage-containing nucleotide pairs<ref>PMID:27035942</ref>.
+
== Disease ==
== Disease ==
-
Mutations in the nucleotide excision repair pathway can cause the xeroderma pigmentosum skin cancer predisposition syndrome<ref>PMID:17882165</ref>.
+
Mutations in '''DNA repair protein Rad4''' can cause the xeroderma pigmentosum skin cancer predisposition syndrome<ref>PMID:17882165</ref>.
== Structural highlights ==
== Structural highlights ==
<scene name='78/780971/Cv/2'>Structure of yeast Rad4 complex with Rad23 and DNA</scene> (PDB entry [[2qsg]]). <scene name='78/780971/Cv/3'>Rad4 β-hairpin</scene> inserts into DNA making hydrogen bond interactions as well as non-bonding interactions with it<ref>PMID:17882165</ref>. <scene name='78/780971/Cv/4'>Residues which interact with DNA are shown as sticks and labled</scene>.
<scene name='78/780971/Cv/2'>Structure of yeast Rad4 complex with Rad23 and DNA</scene> (PDB entry [[2qsg]]). <scene name='78/780971/Cv/3'>Rad4 β-hairpin</scene> inserts into DNA making hydrogen bond interactions as well as non-bonding interactions with it<ref>PMID:17882165</ref>. <scene name='78/780971/Cv/4'>Residues which interact with DNA are shown as sticks and labled</scene>.
-
</StructureSection>
 
-
== 3D Structures of DNA repair protein Rad4 ==
 
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
== 3D Structures of DNA repair protein ==
 +
[[DNA repair protein 3D structures]]
-
[[2qsf]] – yRad4 + Rad23 - yeast<br />
 
-
[[2qsg]], [[2qsh]], [[4yir]], [[6cfi]], [[6ubf]], [[6ug1]], [[6uin]] – yRad4 + Rad23 + DNA <br />
 
-
[[7k04]] – yRad4 + Rad23 + Rad33 + TFIIH + DNA – Cryo EM<br />
 
-
[[7m2u]] – yRad4 + Rad23 + Rad25 + Rad33 + TFIIH + DNA – Cryo EM<br />
 
-
[[2m14]] – yRad4 internal UBA domain + RNA polymerase II TFB1 - NMR<br />
 
-
[[4bu0]], [[4bu1]], [[6hm3]], [[6hm4]] – fyRad4 BRCT1 domain + phosphopeptide – fission yeast<br />
 
-
[[4bmc]] – fyRad4 BRCT1 + BRCT2 domains <br />
 
-
[[4bmd]] – fyRad4 BRCT3 + BRCT4 domains <br />
 
== References ==
== References ==
<references/>
<references/>
 +
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry 2qsg)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/DNA_repair_protein"
Personal tools