User:Yash Patankar/Sandbox 1
From Proteopedia
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chaperones responsible for managing protein folding and quality | chaperones responsible for managing protein folding and quality | ||
control in the crowded environment of the cell [1]. Although | control in the crowded environment of the cell [1]. Although | ||
| - | Hsp90 is involved in the triage of | + | Hsp90 is involved in the triage of misfolded proteins under stress, |
| - | + | ||
| - | + | ||
it also plays a key role under normal conditions in regulating | it also plays a key role under normal conditions in regulating | ||
the stability and activation state of a range of ‘client’ proteins, | the stability and activation state of a range of ‘client’ proteins, | ||
Revision as of 08:07, 4 December 2008
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| 3cin, resolution 1.70Å () | |||||||||
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| Ligands: | , , | ||||||||
| Gene: | TM1419, TM_1419 (Thermotoga maritima MSB8) | ||||||||
| Activity: | Inositol-3-phosphate synthase, with EC number 5.5.1.4 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Hsp90 (90 kDa heat-shock protein) is one of a group of molecular chaperones responsible for managing protein folding and quality control in the crowded environment of the cell [1]. Although Hsp90 is involved in the triage of misfolded proteins under stress, it also plays a key role under normal conditions in regulating the stability and activation state of a range of ‘client’ proteins, many of which are critical for signal transduction [2]. As an extension of its protein-stabilizing role, work in model organisms shows that Hsp90 acts as a buffer or capacitor of genetic variation in morphological evolution [3]. Furthermore, there is strong evidence that Hsp90 plays an important role in disease states, particularly in cancer, where the chaperoning of mutated and overexpressed oncoproteins is critical [4]. This has driven the development of Hsp90 inhibitors for cancer treatment and, potentially, other diseases [5]. Recent systems-biology studies indicate that Hsp90 is a major interaction node, regulating a very diverse set of cellular functions [6,7]
