3kfb

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{{Seed}}
 
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[[Image:3kfb.png|left|200px]]
 
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==Crystal structure of a group II chaperonin from Methanococcus maripaludis==
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The line below this paragraph, containing "STRUCTURE_3kfb", creates the "Structure Box" on the page.
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<StructureSection load='3kfb' size='340' side='right'caption='[[3kfb]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kfb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KFB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3kfb| PDB=3kfb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kfb OCA], [https://pdbe.org/3kfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kfb RCSB], [https://www.ebi.ac.uk/pdbsum/3kfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kfb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q877G8_METMI Q877G8_METMI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/3kfb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kfb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Chaperonins are large protein complexes consisting of two stacked multisubunit rings, which open and close in an ATP-dependent manner to create a protected environment for protein folding. Here, we describe the first crystal structure of a group II chaperonin in an open conformation. We have obtained structures of the archaeal chaperonin from Methanococcus maripaludis in both a peptide acceptor (open) state and a protein folding (closed) state. In contrast with group I chaperonins, in which the equatorial domains share a similar conformation between the open and closed states and the largest motions occurs at the intermediate and apical domains, the three domains of the archaeal chaperonin subunit reorient as a single rigid body. The large rotation observed from the open state to the closed state results in a 65% decrease of the folding chamber volume and creates a highly hydrophilic surface inside the cage. These results suggest a completely distinct closing mechanism in the group II chaperonins as compared with the group I chaperonins.
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===Crystal structure of a group II chaperonin from Methanococcus maripaludis===
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Crystal structures of a group II chaperonin reveal the open and closed states associated with the protein folding cycle.,Pereira JH, Ralston CY, Douglas NR, Meyer D, Knee KM, Goulet DR, King JA, Frydman J, Adams PD J Biol Chem. 2010 Sep 3;285(36):27958-66. Epub 2010 Jun 23. PMID:20573955<ref>PMID:20573955</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3kfb" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20573955}}, adds the Publication Abstract to the page
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*[[Chaperonin 3D structures|Chaperonin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20573955 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20573955}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3KFB is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFB OCA].
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==Reference==
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<ref group="xtra">PMID:20573955</ref><references group="xtra"/>
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[[Category: Methanococcus maripaludis]]
[[Category: Methanococcus maripaludis]]
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[[Category: Adams, P D.]]
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[[Category: Adams PD]]
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[[Category: Douglas, N.]]
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[[Category: Douglas N]]
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[[Category: Frydman, J.]]
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[[Category: Frydman J]]
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[[Category: Goulet, D R.]]
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[[Category: Goulet DR]]
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[[Category: King, J A.]]
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[[Category: King JA]]
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[[Category: Knee, K M.]]
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[[Category: Knee KM]]
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[[Category: Meyer, D.]]
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[[Category: Meyer D]]
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[[Category: Pereira, J H.]]
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[[Category: Pereira JH]]
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[[Category: Ralston, C Y.]]
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[[Category: Ralston CY]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Double homo-octameric ring]]
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[[Category: Nucleotide-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 07:51:17 2010''
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Current revision

Crystal structure of a group II chaperonin from Methanococcus maripaludis

PDB ID 3kfb

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