Fibrin

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[[Image:1n73b.png|left|250px|thumb|Crystal Structure of Fibrin from ''Petromyzon marinus'', [[1n73]]]]
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<StructureSection load='1n73' size='350' side='right' scene='41/417472/Cv/3' caption='Fibrin α1 subunit (red, yellow), β subunit (cyan, blue), γ subunit (orange, magenta) from Petromyzon marinus (PDB entry [[1n73]])'>
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{{STRUCTURE_1n73| PDB=1n73 | SIZE=300| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin from ''Petromyzon marinus'', [[1n73]] }}
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[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. Fibrinogen (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, ''i.e.'' the crystal structure of Fibrin from ''Petromyzon marinus'' ([[1n73]]).
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== Function ==
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{{TOC limit|limit=2}}
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[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa)<ref>PMID:12501189</ref>.
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== Disease ==
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Overexpression of FIa can cause thrombosis.
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== Structural highlights ==
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<scene name='41/417472/Cv/6'>Ca coordination site in β subunit</scene>.
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<scene name='41/417472/Cv/7'>Ca coordination site in γ subunit</scene> (PDB entry [[1n73]]).
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</StructureSection>
== 3D Structures of Fibrin ==
== 3D Structures of Fibrin ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3h32]] – hFIa peptide+ hFI α, β, γ chains – human<br />
[[3h32]] – hFIa peptide+ hFI α, β, γ chains – human<br />
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[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br />
[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br />
[[1n8e]] - hFIa α, β, γ chains <br />
[[1n8e]] - hFIa α, β, γ chains <br />
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[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br />
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[[2a45]] - hFIa α, β, γ chains + thrombin<br />
[[1fzc]] – hDDFIa+peptide<br />
[[1fzc]] – hDDFIa+peptide<br />
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[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br />
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== References ==
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<references/>
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[[Category:Topic Page]]

Current revision

Fibrin α1 subunit (red, yellow), β subunit (cyan, blue), γ subunit (orange, magenta) from Petromyzon marinus (PDB entry 1n73)

Drag the structure with the mouse to rotate

3D Structures of Fibrin

Updated on 02-March-2023

3h32 – hFIa peptide+ hFI α, β, γ chains – human
2q9i, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
2a45 - hFIa α, β, γ chains + thrombin
1fzc – hDDFIa+peptide
1n73 - FIa α, β, γ chains + peptide – Sea lamprey

References

  1. ↑ Yang Z, Pandi L, Doolittle RF. The crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface. Biochemistry. 2002 Dec 31;41(52):15610-7. PMID:12501189

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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