Pharmaceutical Drug Targets and Diseases

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[[Image: Nexium.jpg|300px|right|thumb| AstraZeneca’s Nexium]]
 
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<big>The following is a list of major pharmaceutical compound targets, drugs, and information organized by disease. </big>
<big>The following is a list of major pharmaceutical compound targets, drugs, and information organized by disease. </big>
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**Alzheimer’s Disease
**Alzheimer’s Disease
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***[[2ace|Acetylcholinesterase from Torpedo Californica]]
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***See: [[Alzheimer's Disease]]
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***[[Acetylcholinesterase]]
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***[[Acetylcholine]]
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***[[Flexibility of aromatic residues in acetylcholinesterase|Flexibility of Aromatic Residues in AChE]]
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***[[Amyloid Beta]]
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***[[Acetylcholine binding protein]] (AChBP)
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***[[Butyrylcholinesterase]] (BChE)
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***Drug Compounds & Substrates
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****[[AChE_bivalent_inhibitors|Bivalent Inhibitors of Acetylcholinesterase]]
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****[[AChE_bivalent_inhibitors_%28Part_II%29|Bivalent Inhibitors of Acetylcholinesterase, Part II]]
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****[[AChE_inhibitors_and_substrates|Inhibitors and Substrates of Acetylcholinesterase]]
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****[[ AChE_inhibitors_and_substrates_%28Part_II%29|Inhibitors and Substrates of Acetylcholinesterase, Part II]]
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****[[ AChE_inhibitors_and_substrates_%28Part_III%29|Inhibitors and Substrates of Acetylcholinesterase, Part III]]
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****Specific Examples:
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*****[[1eve|Aricept Complexed with Acetylcholinesterase]]
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*****[[2dfp|DFP (Aged) Complexed with Acetylcholinesterase]]
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*****[[1ax9|Edrophonium Complexed with Acetylcholinesterase]] or [[2ack|Here]]
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*****[[2j3q|Fluorophore Thioflavin T Complexed with Acetylcholinesterase]]
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*****[[1dx6|Galanthamine Complexed with Acetylcholinesterase]]
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*****[[1vot|Huperzine A Complexed with Acetylcholinesterase]]
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*****[[1w6r|Iminium Galanthamine Derivative bound to Acetylcholinesterase]] or [[1w4l|Here]], or [[1w76|Here]].
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-
*****[[1gqs|NAP Complexed with Acetylcholinesterase]]
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*****[[1vxr|O-tthylmethylphosphonylated Acetylcholinesterase]]
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*****[[2wfz|Soman Complexed with Acetylcholinesterase]] or [[2wg0|Here]], or [[2wg1|Here]], or [[1cfj|Here]], or [[1som|Here]].
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*****[[1acj|Tacrine Complexed with Acetylcholinesterase]]
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**** Bivalent Inhibitors
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*****[[1u65|Anticancer Prodrug CPT-11 Complexed with Acetylcholinesterase]]
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*****[[1eve|Aricept Complexed with Acetylcholinesterase]]
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*****[[1w4l|Bis-Acting Galanthamine Derivative Complexed with Acetylcholinesterase]], or [[1w76|Here]], or [[1w6r|Here]]
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*****[[2cmf|Bis-Tacrine Derivative Complexed with Acetylcholinesterase]] or [[2ckm|Here]] or [[1odc|Here]]
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*****[[1acl|Bisquaternary Decamethonium Complexed with Acetylcholinesterase]]
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*****[[1e3q|BW284C51 Complexed with Acetylcholinesterase]]
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*****[[1zgb|Hupyridone Derivative Complexed with Acetylcholinesterase]], or [[1zgc|Here]], or [[1h22|Here]], or [[1h23|Here]]
+
-
*****[[1ut6|N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE Complexed with Acetylcholinesterase]]
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*****[[1jjb|PEG-SH Complexed with Acetylcholinesterase]]
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-
***[[Gamma-Secratase]]
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***Glutamate Receptor
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****[[Glutamate receptor (GluA2)]]
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****[[Molecular_Playground/Glutamate_Receptor|Glutamate Receptor]]
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**Anemia
**Anemia
***[[Erythropoietin]]
***[[Erythropoietin]]
 +
 +
**Antifungal
 +
***[[Noxafil]]
 +
 +
**Antimalarial
 +
***[[Malarial Dihydrofolate Reductase as Drug Target]]
 +
 +
**Anti-parasitic
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***[[Ivermectin|Drug: Ivermectin; Target: Glutamate-gated chloride channels]]
**Asthma and other Pulmonary Disease States
**Asthma and other Pulmonary Disease States
-
***[[Beta-2-Andrenergic Receptor]]
+
***[[Beta-2 Adrenergic Receptor]]
***[[Leukotriene Receptor]]
***[[Leukotriene Receptor]]
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**Autoimmune Diseases
**Autoimmune Diseases
-
***[[Tumor Necrosis Factor Receptor]]
+
***[[Prolyl Endopeptidase]]
 +
***[[Tumor necrosis factor receptor]]
***[[Molecular_Playground/TRAIL|Tumor-Necrosis Factor Apoptosis-Inducing Ligand]]
***[[Molecular_Playground/TRAIL|Tumor-Necrosis Factor Apoptosis-Inducing Ligand]]
**Bacterial Infections
**Bacterial Infections
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***[[Molecular_Playground/PcrA_Helicase|PcrA Helicase]]
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*** See: [[Bacterial Infections]]
 +
***[[Treatment of Tuberculosis]]
**Blood Clots, Haemophilia, & Thrombic Events
**Blood Clots, Haemophilia, & Thrombic Events
***[[P2Y12]]
***[[P2Y12]]
***Haemophilia
***Haemophilia
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****[[Jolanta_amblo|Factor VII]]
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**** See: [[Hemophilia]]
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****[[Factor_IX|Factor IX]]
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***[[Platelet-receptor glycoprotein Ib alpha]]
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****[[Factor_Xa|Factor Xa]]
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**Cancer
**Cancer
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***Caspases
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*** See: [[Cancer]]
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****[[Molecular_Playground/Caspase-6|Caspase-6]]
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****[[Molecular_Playground/Caspase-7_Dynamics|Caspase-7 Dynamics]]
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****[[Molecular_Playground/Caspase-9_Regulation|Caspase-9 Regulation]]
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***[[User:Greg_Black/Sandbox_1|Cisplatin Information]]
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***[[Michael Purol Sandbox 1|Cyclin Dependent Kinase Inhibitor]]
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***[[6-deoxyerythronolide_B_synthase_%28DEBS%29|DEBS]]
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***[[Farnesoid X Receptor]]
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-
***Growth Factors & Receptors
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****Epidermal Growth Factor
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*****[[Epidermal Growth Factor]]
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*****[[Epidermal Growth Factor Receptor]]
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****[[Hepatocyte Growth Factor Receptor]]
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****[[Human Epidermal Growth Factor Receptor 2]]
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****Insulin-Like Growth Factor
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*****[[Insulin-Like Growth Factor-1]]
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*****[[Insulin-Like Growth Factor-1 Receptor]]
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****Vascular Growth Factor
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*****[[Vascular Endothelial Growth Factor]]
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*****[[Vascular Endothelial Growth Factor Receptor]]
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***[[Molecular_Playground/FIH|Hypoxia Inducible Factor (HIF)]]
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***[[Heat Shock Protein 90]]
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***[[1ebm|Human 8-Oxoguanine Glycosylase Structure and Mechanism (HOGG1)]]
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***Kinases
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****[[Cory_Tiedeman_sandbox|Cyclin Dependent Kinase-4]]
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****[[Cell Division Cycle 7-Related Protein Kinase]]
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****[[Mammalian Target of Rapamycin]]
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****Mitogen-Activated Proteins
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*****Mitogen-Activated Protein Kinase
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*****Mitogen-Activated Protein Kinase Kinase
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*****Mitogen-Activated Protein Kinase Kinase Kinase
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-
******[[c-Raf]]
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****[[Phosphatidylinositol 3-Kinase]]
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****[[SRC]]
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***[[Matt Routh sandbox|MDM2 Bound to p53]]
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***[[P-glycoprotein:_Why_Cancer_Drugs_Fail|P-Glycoprotein: Why Cancer Drugs Fail]]
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***[[p53]]
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***[[Ann_Taylor_sandbox_Proteins_in_Cancer|Proteins in Cancer]]
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***[[Chad Sorenson sandbox 1|Retinoblastoma Protein]]
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***[[Molecular_Playground/Taxol|Taxol Information]]
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***[[Molecular_Playground/TRAIL|Tumor-Necrosis Factor Apoptosis-Inducing Ligand]]
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-
***[[Molecular_Playground/YKL-40|YKL-40]]
+
**Compromised Immune System
**Compromised Immune System
***[[Granulocyte-macrophage colony-stimulating factor]]
***[[Granulocyte-macrophage colony-stimulating factor]]
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**Delivery Systems
+
**Delivery Systems & Biotech
***[[Molecular_Playground/Targeting_Peptide|Targeted Drug Delivery]]
***[[Molecular_Playground/Targeting_Peptide|Targeted Drug Delivery]]
 +
***[[Monoclonal Antibody]]
**Diabetes & Hypoglycemia
**Diabetes & Hypoglycemia
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***[[Molecular_Playground/Insulin|Insulin Information]]
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*** See: [[Diabetes]]
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***[[User:Mary Ball/Leptin|Leptin]]
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***[[Peroxisome Proliferator-Activated Receptors]]
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***[[Molecular_Playground/YKL-40|YKL-40]]
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**Digestive Diseases
**Digestive Diseases
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***[[Proton Pump]]
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***Proton Pump
 +
****[[Esomeprazole and H+/K+ - ATPase Interaction]]
**Erectile Dysfunction
**Erectile Dysfunction
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**Hypertension & Congestive Heart Failure
**Hypertension & Congestive Heart Failure
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***[[Angiotensin-Converting Enzyme]]
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***See: [[Hypertension & Congestive Heart Failure]]
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***[[Calcium Channel]]
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**Inflammation & Rheumatoid Arthritis
**Inflammation & Rheumatoid Arthritis
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***[[Cyclooxygenase]]
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***[[Inflammation & Rheumatoid Arthritis]]
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***[[Aspirin effects on COX aka PGHS|Asprin Effects on Cyclooxygenase]]
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***[[Molecular_Playground/YKL-40|YKL-40]]
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**Metabolic Disorders
**Metabolic Disorders
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***[[Acid-beta-glucosidase]]
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*** See: [[Metabolic Disorders]]
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***[[Molecular_playground/beta_2_microglobulin|ß-2 Microglobulin]]
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***[[Molecular_Playground/Human_PPCA|Protective Protein/Cathepsin A (PPCA)]]
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***[[Molecular_Playground/Human_Protective_Protein_Cathepsin_A|Protective Protein/Cathepsin A (PPCA) 2]]
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***[[Treatment_of_Gaucher_disease]]
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***[[Molecular_Playground/Velaglucerase|Velaglucerase]]
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-
**Schizophrenia, Bipolar Depression, Insomnia, and Anxiety Disorders
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**Schizophrenia, Bipolar Depression, Depression, Insomnia, and Anxiety Disorders
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***[[Dopamine Receptor]]
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***[[Dopamine receptor]]
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***[[Andrenergic Receptor]]
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***[[Adrenergic receptor]]
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***[[Histamine Receptor]]
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***[[Histamine H1 receptor]]
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***[[Opioid Receptor]]
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***[[Opioid receptor]]
 +
***[[5-hydroxytryptamine receptor]]
**Viral Infection
**Viral Infection
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***[[Molecular_Playground/T7_RNA_Polymerase_%287_mer_int%29|T7 RNA Polymerase]]
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***[[Molecular_Playground/T7_RNA_Polymerase_%287_mer_int%29| T7 RNA Polymerase]]
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***HIV
+
*** HIV
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****[[HIV-1 protease|HIV-1 Protease]]
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**** See: [[Human Immunodeficiency Virus]]
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****[[User:Tsung-Yi_Lin/Sandbox|HIV-1 Protease Analysis]]
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*** Influenza
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****[[HIV-1 Gag]]
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**** See: [[Influenza]]
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****[[HIV-1 Gag Recruitment of Tsg101 and the Viral Budding Process]]
+
*** [[Herpes Simplex Virus Thymidine Kinase]]
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****[[User:Eric Martz/Molecular Playground/HIVDrug|HIV Drug]]
+
*** [[NS5B|RNA Dependent RNA Polymerase from Hepatitis C Virus]]
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****[[Molecular_Playground/HIV_Protease_Inhibitor|HIV Protease Inhibitor]]
+
*** Poliovirus
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****[[HIV-1_Subtype_C_Protease|HIV-1 Subtype C Protease]]
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****[[Journal:PLoS ONE:1|Antiviral Activity of 3(2H)- and 6-Chloro-3(2H)-Isoflavenes against Highly Diverged, Neurovirulent Vaccine-Derived, Type2 Poliovirus Sewage Isolates]]
-
****[[Reverse Transcriptase]]
+
*** [[Interferon]]
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***Influenza
+
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**** [[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
+
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**** [[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
+
-
****H1N1 Sequence Analyses
+
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****** [[User:Michael_Strong/H1N1|H1N1 Swine Flu Sequence Analysis]]
+
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****** [[User:Michael_Strong/H1N1/MP1/MSA|H1N1 Swine Flu Multiple Sequence Alignment]]
+
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****** [[User:Michael Strong/H1N1/MP2/MSA|H1N1 Sequence Alignment of MP2 Protein]]
+
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****** [[User:Michael_Strong/H1N1/PB2|H1N1 Sequence Alignment of PB2 Protein]]
+
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****** [[User:Michael_Strong/H1N1/PB1|H1N1 Sequence Alignment of PB1 Protein]]
+
-
****** [[User:Michael_Strong/H1N1/NS2/MSA|H1N1 Sequence Alignment of NS2 Protein]]
+
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****** [[User:Michael_Strong/H1N1/PA|H1N1 Sequence Alignment of PA Protein]]
+
-
****** [[User:Michael_Strong/H1N1/HA|H1N1 Sequence Alignment of HA Protein]]
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-
****** [[User:Michael_Strong/H1N1/NP|H1N1 Sequence Alignment of NP Protein]]
+
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****** [[User:Michael_Strong/H1N1/NA|H1N1 Sequence Alignment of NA Protein]]
+
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****** [[User:Michael_Strong/H1N1/MP|H1N1 Sequence Alignment of MP Protein]]
+
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****** [[User:Michael_Strong/H1N1/NS|H1N1 Sequence Alignment of NS Protein]]
+
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**** [[Influenza hemagglutinin]]
+
-
**** [[Molecular_Playground/Influenza_A_M2_transmembrane_domain|Influenza A M2 Transmembrane Domain]]
+
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**** [[Proton Channels]] featuring a morph of the M2 proton channel of influenza.
+
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**** [[Molecular Playground/Tamiflu|Tamiflu]]
+
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**** [[Molecular Playground/Relenza|Relenza]]
+
}}
}}
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See [[Pharmaceutical Drugs]] for descriptions and analysis of well known drugs

Current revision

The following is a list of major pharmaceutical compound targets, drugs, and information organized by disease.

See Pharmaceutical Drugs for descriptions and analysis of well known drugs

Retrieved from "http://52.214.119.220/wiki/index.php/Pharmaceutical_Drug_Targets_and_Diseases"
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