B-RAF with PLX4032

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<applet load='3og7' size='800' color='white' frame='true' align='right' caption='testcaption' />
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<applet load='3og7' size='400' color='white' frame='true' align='right' caption='BRAF kinase domain complex with PLX4032 (PDB code [[3og7]])' />
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<scene name='B-RAF_with_PLX4032/Plx_4032_only/1'>PLX 4032</scene><br>
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<scene name='B-RAF_with_PLX4032/Plx_4032_only/2'>PLX 4032</scene><br>
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<scene name='B-RAF_with_PLX4032/Atp/1'>ATP</scene><br>
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<scene name='B-RAF_with_PLX4032/Atp/2'>ATP</scene><br>
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<scene name='B-RAF_with_PLX4032/Wild-type_b-raf/1'>Wild-Type B-RAF</scene> <br>
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<scene name='B-RAF_with_PLX4032/Wild-type_b-raf/2'>Wild-Type B-RAF</scene> <br>
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<scene name='B-RAF_with_PLX4032/Mutated_v600e/1'>V600E Mutation</scene> <br>
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<scene name='B-RAF_with_PLX4032/Mutated_v600e/2'>V600E Mutation</scene> <br>
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<scene name='B-RAF_with_PLX4032/Plx4032_n/1'>PLX4032 Sulfonamide N</scene> <br>
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<scene name='B-RAF_with_PLX4032/H-bond/4'>H-Bond Interaction Asp594 and PLX4032</scene><br>
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<scene name='B-RAF_with_PLX4032/H-bond/3'>H-Bond Interaction Asp594 and PLX4032</scene><br>
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<scene name='B-RAF_with_PLX4032/Superposition3og71uwh/4'>Superposition overview</scene> <br>
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<scene name='B-RAF_with_PLX4032/Dfg_in_conformation/1'>DFG in</scene><br>
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<scene name='B-RAF_with_PLX4032/Superposition3og71uwh/5'>Superposition close up</scene> <br>
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<scene name='B-RAF_with_PLX4032/Phe_595_dfg_out/1'>DFG out</scene><br>
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<scene name='B-RAF_with_PLX4032/Superposition3og71uwh/2'>Superposition active site</scene> <br>
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<scene name='B-RAF_with_PLX4032/Superposition3og71uwh/1'>Superposition</scene> <br>
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<scene name='B-RAF_with_PLX4032/Confirmation_change_dfg-in/1'>Confirmation Change DFG-In</scene> <br>
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<scene name='B-RAF_with_PLX4032/Confirmation_change_dfg-out/1'>Confirmation Change DFG-Out</scene>
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Current revision

B-RAF with PLX4032

PLX4032 is a newly synthesized drug that is being used to treat malignant melanoma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF.


BRAF kinase domain complex with PLX4032 (PDB code 3og7)

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Proteopedia Page Contributors and Editors (what is this?)

J.D. Woodruff, Jens Hemmingsen, Michal Harel

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