Cardiotoxin

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[[Image:2cdx.png|left|200px|thumb|NMR Structure of cardiotoxin CTX I from ''Naja naja atra'' [[2cdx]]]]
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<StructureSection load='2cdx' size='350' side='right' scene='42/425149/Cv/2' caption='Cardiotoxin CTX I [[2cdx]]'>
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{{STRUCTURE_2cdx| PDB=2cdx | SIZE=300| SCENE=Cardiotoxin/Cv/1 |right|CAPTION=Cardiotoxin CTX I [[2cdx]] }}
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[[Cardiotoxin]] (CTX) is a snake toxin from the Taiwan cobra Naja naja. The cardiotoxin from the Malayan krait is called bucain. The images at the left and at the right correspond to one representative CTX, ''i.e.'' the NMR structure of cardiotoxin CTX I from ''Naja naja atra'' ([[2cdx]]).
 
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{{TOC limit|limit=2}}
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== Function ==
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'''Cardiotoxin''' or '''cytotoxin''' (CTX) is a snake toxin from the Taiwan cobra ''Naja naja''. The cardiotoxin from the Malayan krait is called '''bucain'''. CTX perturb the membrane structure of cells by interaction with lipids. <ref>PMID:3472200</ref> For toxins in Proteopedia see [[Toxins]].<br />
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== Relevance ==
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'''Cardiotoxin I''' causes necrosis of skeletal muscle cells.
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'''Cardiotoxin III''' induces apoptosis in K562 cells.
== 3D Structures of Cardiotoxin ==
== 3D Structures of Cardiotoxin ==
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[[Cardiotoxin 3D structures]]
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Cardiotoxin
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</StructureSection>
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[[2cdx]] - NaCTX I – NMR – ''Naja atra''<br />
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== References ==
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[[1cre]], [[1crf]] - NaCTX II – NMR<br />
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<references />
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[[2ccx]] – NmCTX II – ''Naja mossambica'' – NMR<br />
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[[1cdt]] – NmCTX II<br />
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[[1ffj]], [[1cb9]], [[1ccq]] – CTX II – ''Naja oxiana'' – NMR<br />
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[[1i02]], [[2crs]], [[2crt]] - NaCTX III – NMR<br />
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[[1xt3]], [[1h0j]] – NaCTX III<br />
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[[1kbs]], [[1kbt]] - NaCTX IV – NMR<br />
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[[1chv]], [[1cvo]] – NaCTX V – NMR<br />
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[[1kxi]] - NaCTX V<br />
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[[1ug4]] – CTX VI<br />
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[[1cxn]], [[1cxo]], [[1tgx]] – γ-CTX – ''Naja nigricollis'' - NMR<br />
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[[2h8u]] – Bucain<br />
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[[Category:Topic Page]]
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[[2bhi]] – CTX III+sulfogalactoceramide<br />
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Current revision

Cardiotoxin CTX I 2cdx

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References

  1. ↑ Rees B, Samama JP, Thierry JC, Gilibert M, Fischer J, Schweitz H, Lazdunski M, Moras D. Crystal structure of a snake venom cardiotoxin. Proc Natl Acad Sci U S A. 1987 May;84(10):3132-6. PMID:3472200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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