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Leucine-rich repeat

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A large family of over 60,000 proteins feature horseshoe- or arc-shaped domains made of leucine-rich repeats, which are named for a repeated motif that always contains leucine.<ref>PMID: 20825685</ref>
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The leucine-rich repeat (LRR) proteins are a large family of over 60,000 proteins found in viruses, bacteria, archaea, and eukaryotes that feature horseshoe- or arc-shaped domains made of leucine-rich repeating motifs.<ref>PMID: 20825685</ref> Presently, at least 144 structures with leucine-rich repeats are deposited at the [http://www.pdb.org/pdb/home/home.do RCSB Protein Data Bank].<ref>LRRML Database (Version 1.6: Released November 25, 2010): Conformational LRR XML-Database at http://tollml.lrz.de:8081/exist/rest//lrrml/releases/releases.xq</ref>
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{{Structure
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{{Template:Lrrapplet1}}
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|PDB= 3e6j |SIZE=400|SCENE=Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1|CAPTION= Lamprey Variable Lymphocyte Receptor ([[3e6j]]), resolution 1.67&Aring; (<scene name='Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1'>initial scene</scene>)
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<!--
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|SITE=
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<slideshow sequence="random" transition="fade" align="left" refresh="5500">
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|LIGAND=
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<div>[[Image:1m10complexsurf.png|330px|left|thumb| <span style="font-size:1.2em;">The human leucine-rich repeat family member [[Platelet-receptor glycoprotein Ib alpha|Platelet-receptor glycoprotein Ib alpha (blue) involved in Willebrand disease bound to the von Willebrand Factor A1 Domain (green surface)]].</span>]] </div>
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|ACTIVITY=
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<div>[[Image:1id5polyview3d.png|center|thumb|330px|<span style="font-size:1.2em;">Extracellular domain of Lingo-1 protein involved in inhibiting effective regrowth of axons after central nervous system damage, from [[2id5]].</span>]] </div>
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|GENE=
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<div>[[Image:3ciyPV3D.png|left|thumb|360px|<span style="font-size:1.2em;">Extracellular domain of mouse Toll-like receptor bound to double-stranded RNA which is a molecular signature of many viruses, from [[3ciy]].</span>]] </div>
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|DOMAIN=
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</slideshow>
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|RELATEDENTRY=
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-->
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6j OCA], [http://www.ebi.ac.uk/pdbsum/3e6j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3e6j RCSB]</span>
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}}
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<br>&nbsp;<br>
Articles in Proteopedia concerning Leucine-rich repeat proteins include:
Articles in Proteopedia concerning Leucine-rich repeat proteins include:
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*[[Human Follicle-Stimulating Hormone Complexed with its Receptor]]
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**[[1xvd|Human Follicle Stimulating Hormone Complexed with its Receptor]]
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*[[Variable lymphocyte receptor]]
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**[[Variable Lymphocyte Receptors]]
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*[[Lamprey Variable Lymphocyte Receptor]]
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**[[Lamprey Variable Lymphocyte Receptor]]
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*[[3g04|Leucine-rich repeat domain of Thyroid-Stimulating Hormone]]
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*[[Toll-like Receptors|Toll-like receptors (TLRs)]], such as [[3ciy|Mouse Toll-like receptor bound to dsRNA]]
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*[[Platelet-receptor glycoprotein Ib alpha|Platelet-receptor glycoprotein Ib alpha bound to the von Willebrand Factor A1 Domain]]
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*[[2id5|Lingo-1 protein involved in inhibiting effective regrowth of axons after central nervous system damage]]
<br />
<br />
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<!--
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{{Template:Lrrapplet2}}
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-->
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To view automatically seeded indices concerning Leucine-rich repeat proteins<ref>PMID: 20825685</ref><ref>LRRML Database (Version 1.6: Released November 25, 2010): Conformational LRR XML-Database at http://tollml.lrz.de:8081/exist/rest//lrrml/releases/releases.xq</ref>, see:
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*[[:Category:Leucine-rich repeat|Leucine-rich repeat]]
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*[[:Category:Leucine-rich-repeat|Leucine-rich-repeat]]
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*[[:Category:Leucine-rich repeat-containing protein 4|Leucine-rich repeat-containing protein 4]]
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*[[:Category:Lrr|LRR]]
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*[[:Category:Leucine-rich repeat glycoprotein|Leucine-rich repeat glycoprotein]]
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{{STRUCTURE_1xwd| PDB=1xwd | SCENE= }}
 
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To view automatically seeded indices concerning Leucine-rich repeat proteins, see:
 
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**[[:Category:Leucine-rich repeat|Leucine-rich repeat]]
 
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**[[:Category:Leucine-rich-repeat|Leucine-rich-repeat]]
 
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**[[:Category:Leucine-rich repeat-containing protein 4|Leucine-rich repeat-containing protein 4]]
 
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**[[:Category:Lrr|LRR]]
 
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**[[:Category:Leucine-rich repeat glycoprotein|Leucine-rich repeat glycoprotein]]
 
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==References==
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==References and Notes==
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<references/>
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<references/> <!--Seems div for slideshow messed up connection to references above?-->
==See Also==
==See Also==
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*[[Toll-like Receptors|Toll-like receptors (TLRs)]]
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*[[Antibody]]
==Additional Literature==
==Additional Literature==
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<ref group="xtra">PMID: 11751054</ref><ref group="xtra">PMID: 17517123</ref><ref group="xtra">PMID: 16231091</ref><ref group="xtra">PMID: 11967365</ref><references group="xtra"/>
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<ref group="xtra">PMID: 11751054</ref><ref group="xtra">PMID: 17517123</ref><ref group="xtra">PMID: 19728889 </ref><ref group="xtra">PMID: 16231091</ref><ref group="xtra">PMID: 11967365</ref><ref group="xtra">PMID: 18510864</ref><ref group="xtra">PMID: 19627256</ref><ref group="xtra">PMID: 18986514</ref><ref group="xtra">PMID: 20084417</ref><references group="xtra"/>
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==External Resources==
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*[http://tollml.lrz.de:8081/exist/rest//lrrml/index.xq LRRML: a conformational database and an XML description of leucine-rich repeats (LRRs)]
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*[http://tollml.lrz.de:8081/exist/rest//db/tollml/index.xq TOLLML Database: database of toll-like receptor structural motifs]
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* [http://www.ssfa-gphr.de/index.php Web-Based Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors site] features coverage of the ectodomain which hosts a series of leucine-rich repeats
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[[Category:Topic Page]]

Current revision

The leucine-rich repeat (LRR) proteins are a large family of over 60,000 proteins found in viruses, bacteria, archaea, and eukaryotes that feature horseshoe- or arc-shaped domains made of leucine-rich repeating motifs.[1] Presently, at least 144 structures with leucine-rich repeats are deposited at the RCSB Protein Data Bank.[2]

 

Drag the structure with the mouse to rotate
Lamprey Variable Lymphocyte Receptor bound to a trisaccharide antigen (3e6j), resolution 1.67Å



 

Articles in Proteopedia concerning Leucine-rich repeat proteins include:


To view automatically seeded indices concerning Leucine-rich repeat proteins[3][4], see:


Contents

References and Notes

  1. ↑ Matsushima N, Miyashita H, Mikami T, Kuroki Y. A nested leucine rich repeat (LRR) domain: the precursor of LRRs is a ten or eleven residue motif. BMC Microbiol. 2010 Sep 9;10:235. PMID:20825685 doi:10.1186/1471-2180-10-235
  2. ↑ LRRML Database (Version 1.6: Released November 25, 2010): Conformational LRR XML-Database at http://tollml.lrz.de:8081/exist/rest//lrrml/releases/releases.xq
  3. ↑ Matsushima N, Miyashita H, Mikami T, Kuroki Y. A nested leucine rich repeat (LRR) domain: the precursor of LRRs is a ten or eleven residue motif. BMC Microbiol. 2010 Sep 9;10:235. PMID:20825685 doi:10.1186/1471-2180-10-235
  4. ↑ LRRML Database (Version 1.6: Released November 25, 2010): Conformational LRR XML-Database at http://tollml.lrz.de:8081/exist/rest//lrrml/releases/releases.xq

See Also

Additional Literature

  • Kobe B, Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol. 2001 Dec;11(6):725-32. PMID:11751054
  • Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K, Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics. 2007 May 21;8:124. PMID:17517123 doi:10.1186/1471-2164-8-124
  • Istomin AY, Godzik A. Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs. BMC Immunol. 2009 Sep 3;10:48. PMID:19728889 doi:10.1186/1471-2172-10-48
  • Matsushima N, Tachi N, Kuroki Y, Enkhbayar P, Osaki M, Kamiya M, Kretsinger RH. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. Cell Mol Life Sci. 2005 Dec;62(23):2771-91. PMID:16231091 doi:10.1007/s00018-005-5187-z
  • Kajava AV, Kobe B. Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Sci. 2002 May;11(5):1082-90. PMID:11967365 doi:10.1110/ps.4010102
  • Jin MS, Lee JO. Application of hybrid LRR technique to protein crystallization. BMB Rep. 2008 May 31;41(5):353-7. PMID:18510864
  • Carpenter S, O'Neill LA. Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem J. 2009 Jul 29;422(1):1-10. PMID:19627256 doi:10.1042/BJ20090616
  • Wei T, Gong J, Jamitzky F, Heckl WM, Stark RW, Rossle SC. LRRML: a conformational database and an XML description of leucine-rich repeats (LRRs). BMC Struct Biol. 2008 Nov 5;8:47. PMID:18986514 doi:10.1186/1472-6807-8-47
  • Gong J, Wei T, Zhang N, Jamitzky F, Heckl WM, Rossle SC, Stark RW. TollML: a database of toll-like receptor structural motifs. J Mol Model. 2010 Jul;16(7):1283-9. Epub 2010 Jan 19. PMID:20084417 doi:10.1007/s00894-009-0640-9

External Resources

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