Sandbox c99

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<Structure load='1stp' size='500' frame='true' align='right' caption='Insert caption here' />Hola, que tal?
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<Structure load='1acj' size='300' frame='true' align='right' caption='Mi structura favorita' />
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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.<ref>PMID 123</ref><ref>PMID 434343</ref>
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Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
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It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
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Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330
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<scene name='Sandbox_c99/Tacrine1/1'>(W84 and F330)</scene>
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<ref>PMID 8415649</ref>
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Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
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<references/>

Current revision

Mi structura favorita

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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.[1][2]

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330

[3]

Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

  1. ↑ Keighley MR, Asquith P, Edwards JA, Alexander-Williams J. The importance of an innervated and intact antrum and pylorus in preventing postoperative duodenogastric reflux and gastritis. Br J Surg. 1975 Oct;62(10):845-9. PMID:123
  2. ↑ Okoev GG, Kirakosian SA, Kagramanian RG. [Comparative evaluation of the course of labor after use of prostaglandin F2-alpha and oxytocin]. Akush Ginekol (Mosk). 1979 Jan;(1):17-8. PMID:434343
  3. ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
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