1q5r

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[[Image:1q5r.png|left|200px]]
 
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==The Rhodococcus 20S proteasome with unprocessed pro-peptides==
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The line below this paragraph, containing "STRUCTURE_1q5r", creates the "Structure Box" on the page.
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<StructureSection load='1q5r' size='340' side='right'caption='[[1q5r]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q5r]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q5R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5r OCA], [https://pdbe.org/1q5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q5r RCSB], [https://www.ebi.ac.uk/pdbsum/1q5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q5r ProSAT]</span></td></tr>
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{{STRUCTURE_1q5r| PDB=1q5r | SCENE= }}
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</table>
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== Function ==
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===The Rhodococcus 20S proteasome with unprocessed pro-peptides===
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[https://www.uniprot.org/uniprot/PSB1_RHOER PSB1_RHOER] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The R.erythropolis proteasomes are able to cleave oligopeptides after Tyr, Phe and Leu, very poorly after Arg but not after Glu. Thus, displays chymotrypsin-like activity, low trypsin-like activity but no caspase-like activity.[HAMAP-Rule:MF_02113]<ref>PMID:7583123</ref> <ref>PMID:9000518</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 14659753 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/1q5r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_14659753}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q5r ConSurf].
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[[1q5r]] is a 14 chain structure of [[Proteasome]] with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5R OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Proteasome]]
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:14659753</ref><references group="xtra"/>
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__TOC__
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[[Category: Proteasome endopeptidase complex]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rhodococcus erythropolis]]
[[Category: Rhodococcus erythropolis]]
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[[Category: Adams, P D.]]
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[[Category: Adams PD]]
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[[Category: Baumeister, W.]]
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[[Category: Baumeister W]]
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[[Category: Jap, B K.]]
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[[Category: Jap BK]]
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[[Category: Kwon, Y D.]]
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[[Category: Kwon YD]]
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[[Category: Nagy, I.]]
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[[Category: Nagy I]]
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[[Category: Hydrolase]]
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[[Category: Inter-subunit contact]]
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[[Category: Pro-peptide]]
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[[Category: Proteasome assembly]]
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[[Category: Rhodococcus erythropoli]]
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Current revision

The Rhodococcus 20S proteasome with unprocessed pro-peptides

PDB ID 1q5r

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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