3nzx

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[[Image:3nzx.jpg|left|200px]]
 
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==Crystal structure of the yeast 20S proteasome in complex with ligand 2c==
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The line below this paragraph, containing "STRUCTURE_3nzx", creates the "Structure Box" on the page.
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<StructureSection load='3nzx' size='340' side='right'caption='[[3nzx]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3nzx]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NZX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABN:BENZYLAMINE'>ABN</scene>, <scene name='pdbligand=BOC:TERT-BUTYL+HYDROGEN+CARBONATE'>BOC</scene>, <scene name='pdbligand=RE3:3-[(3S)-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-L-ALANINE'>RE3</scene>, <scene name='pdbligand=TY5:O-BENZYL-L-TYROSINE'>TY5</scene></td></tr>
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{{STRUCTURE_3nzx| PDB=3nzx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nzx OCA], [https://pdbe.org/3nzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nzx RCSB], [https://www.ebi.ac.uk/pdbsum/3nzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nzx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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===Crystal structure of the yeast 20S proteasome in complex with ligand 2c===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3nzx]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZX OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:20715286</ref><references group="xtra"/>
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Basse, N.]]
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[[Category: Basse N]]
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[[Category: Gallastegui, N.]]
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[[Category: Gallastegui N]]
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[[Category: Genin, E.]]
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[[Category: Genin E]]
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[[Category: Groll, M.]]
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[[Category: Groll M]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Marechal, X.]]
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[[Category: Le Ravalec V]]
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[[Category: Moroder, M.]]
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[[Category: Marechal X]]
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[[Category: Ravalec, V Le.]]
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[[Category: Moroder M]]
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[[Category: Reboud-Ravaux, M.]]
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[[Category: Reboud-Ravaux M]]
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[[Category: Richy, N.]]
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[[Category: Richy N]]
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[[Category: Vidal, V.]]
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[[Category: Vidal V]]

Current revision

Crystal structure of the yeast 20S proteasome in complex with ligand 2c

PDB ID 3nzx

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