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- | [[Image:3qwx.png|left|200px]] | |
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- | <!--
| + | ==CED-2 1-174== |
- | The line below this paragraph, containing "STRUCTURE_3qwx", creates the "Structure Box" on the page.
| + | <StructureSection load='3qwx' size='340' side='right'caption='[[3qwx]], [[Resolution|resolution]] 2.01Å' scene=''> |
- | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | == Structural highlights == |
- | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | <table><tr><td colspan='2'>[[3qwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWX FirstGlance]. <br> |
- | or leave the SCENE parameter empty for the default display.
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> |
- | --> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
- | {{STRUCTURE_3qwx| PDB=3qwx | SCENE= }}
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwx OCA], [https://pdbe.org/3qwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwx RCSB], [https://www.ebi.ac.uk/pdbsum/3qwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwx ProSAT]</span></td></tr> |
| + | </table> |
| + | == Function == |
| + | [https://www.uniprot.org/uniprot/CED2_CAEEL CED2_CAEEL] Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).<ref>PMID:10707082</ref> <ref>PMID:11449278</ref> <ref>PMID:15744306</ref> <ref>PMID:1936965</ref> <ref>PMID:19402756</ref> <ref>PMID:6857247</ref> |
| | | |
- | ===CED-2 1-174=== | + | ==See Also== |
- | | + | *[[Cell death protein 3D structures|Cell death protein 3D structures]] |
- | | + | == References == |
- | <!--
| + | <references/> |
- | The line below this paragraph, {{ABSTRACT_PUBMED_21616056}}, adds the Publication Abstract to the page
| + | __TOC__ |
- | (as it appears on PubMed at http://www.pubmed.gov), where 21616056 is the PubMed ID number.
| + | </StructureSection> |
- | -->
| + | |
- | {{ABSTRACT_PUBMED_21616056}}
| + | |
- | | + | |
- | ==About this Structure==
| + | |
- | [[3qwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWX OCA]. | + | |
- | | + | |
- | ==Reference== | + | |
- | <ref group="xtra">PMID:021616056</ref><references group="xtra"/> | + | |
| [[Category: Caenorhabditis elegans]] | | [[Category: Caenorhabditis elegans]] |
- | [[Category: Kang, Y.]] | + | [[Category: Large Structures]] |
- | [[Category: Liu, Y.]] | + | [[Category: Kang Y]] |
- | [[Category: Sun, J.]] | + | [[Category: Liu Y]] |
- | [[Category: Cell engulfment]] | + | [[Category: Sun J]] |
- | [[Category: Signaling protein]]
| + | |
| Structural highlights
Function
CED2_CAEEL Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).[1] [2] [3] [4] [5] [6]
See Also
References
- ↑ Reddien PW, Horvitz HR. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol. 2000 Mar;2(3):131-6. PMID:10707082 doi:http://dx.doi.org/10.1038/35004000
- ↑ Reddien PW, Cameron S, Horvitz HR. Phagocytosis promotes programmed cell death in C. elegans. Nature. 2001 Jul 12;412(6843):198-202. PMID:11449278 doi:http://dx.doi.org/10.1038/35084096
- ↑ Kinchen JM, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, Schnabel R, Hengartner MO. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature. 2005 Mar 3;434(7029):93-9. PMID:15744306 doi:http://dx.doi.org/nature03263
- ↑ Ellis RE, Jacobson DM, Horvitz HR. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 1991 Sep;129(1):79-94. PMID:1936965
- ↑ Hurwitz ME, Vanderzalm PJ, Bloom L, Goldman J, Garriga G, Horvitz HR. Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans. PLoS Biol. 2009 Apr 28;7(4):e99. doi: 10.1371/journal.pbio.1000099. PMID:19402756 doi:http://dx.doi.org/10.1371/journal.pbio.1000099
- ↑ Hedgecock EM, Sulston JE, Thomson JN. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. Science. 1983 Jun 17;220(4603):1277-9. PMID:6857247
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