3oev

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[[Image:3oev.png|left|200px]]
 
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==Structure of yeast 20S open-gate proteasome with Compound 25==
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The line below this paragraph, containing "STRUCTURE_3oev", creates the "Structure Box" on the page.
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<StructureSection load='3oev' size='340' side='right'caption='[[3oev]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3oev]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OEV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3OE:4-(BENZYLOXY)-N-[(2S,3R)-3-HYDROXY-1-{[(2S)-1-{[(3-METHYLTHIOPHEN-2-YL)METHYL]AMINO}-1-OXO-4-PHENYLBUTAN-2-YL]AMINO}-1-OXOBUTAN-2-YL]BENZAMIDE'>3OE</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3oev| PDB=3oev | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oev OCA], [https://pdbe.org/3oev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oev RCSB], [https://www.ebi.ac.uk/pdbsum/3oev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oev ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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===Structure of yeast 20S open-gate proteasome with Compound 25===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_20875739}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20875739 is the PubMed ID number.
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Sintchak MD]]
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{{ABSTRACT_PUBMED_20875739}}
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==About this Structure==
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[[3oev]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OEV OCA].
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==Reference==
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<ref group="xtra">PMID:020875739</ref><references group="xtra"/>
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Sintchak, M D.]]
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[[Category: 20s proteasome]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Structure of yeast 20S open-gate proteasome with Compound 25

PDB ID 3oev

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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