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3tdd

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[[Image:3tdd.png|left|200px]]
 
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==Crystal structure of yeast CP in complex with Belactosin C==
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The line below this paragraph, containing "STRUCTURE_3tdd", creates the "Structure Box" on the page.
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<StructureSection load='3tdd' size='340' side='right'caption='[[3tdd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tdd]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TDD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFO:BENZYL+N-[(NAPHTHALEN-2-YLMETHOXY)CARBONYL]-L-ALANYL-N~5~-[(2R,3S,4S)-3-FORMYL-2-HYDROXY-4-METHYLHEXANOYL]-L-ORNITHINATE'>BFO</scene></td></tr>
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{{STRUCTURE_3tdd| PDB=3tdd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tdd OCA], [https://pdbe.org/3tdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tdd RCSB], [https://www.ebi.ac.uk/pdbsum/3tdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tdd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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===Crystal structure of yeast CP in complex with Belactosin C===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_21946808}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21946808 is the PubMed ID number.
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Groll M]]
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{{ABSTRACT_PUBMED_21946808}}
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[[Category: Korotkov VS]]
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[[Category: Larionov OV]]
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==About this Structure==
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[[Category: Ludwig A]]
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[[3tdd]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDD OCA].
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[[Category: Lygin AV]]
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[[Category: De Meijere A]]
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==Reference==
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<ref group="xtra">PMID:021946808</ref><references group="xtra"/>
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Groll, M.]]
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[[Category: Korotkov, V S.]]
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[[Category: Larionov, O V.]]
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[[Category: Ludwig, A.]]
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[[Category: Lygin, A V.]]
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[[Category: Meijere, A de.]]
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[[Category: Beta-sandwich flanked by alpha-helice]]
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[[Category: Drug development]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Primed substrate binding channel]]
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[[Category: Proteasome]]
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[[Category: Ubiquitin]]
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Current revision

Crystal structure of yeast CP in complex with Belactosin C

PDB ID 3tdd

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