3shj

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[[Image:3shj.png|left|200px]]
 
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==Proteasome in complex with hydroxyurea derivative HU10==
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The line below this paragraph, containing "STRUCTURE_3shj", creates the "Structure Box" on the page.
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<StructureSection load='3shj' size='340' side='right'caption='[[3shj]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3shj]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H10:1-HYDROXY-1-[(2R)-4-{3-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YLOXY]PHENYL}BUT-3-YN-2-YL]UREA'>H10</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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{{STRUCTURE_3shj| PDB=3shj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3shj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shj OCA], [https://pdbe.org/3shj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3shj RCSB], [https://www.ebi.ac.uk/pdbsum/3shj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3shj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSB6_YEAST PSB6_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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===Proteasome in complex with hydroxyurea derivative HU10===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22105886}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22105886 is the PubMed ID number.
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Arciniega M]]
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{{ABSTRACT_PUBMED_22105886}}
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[[Category: Beck P]]
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[[Category: Gallastegui N]]
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==About this Structure==
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[[Category: Groll M]]
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[[3shj]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHJ OCA].
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[[Category: Hillebrand S]]
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[[Category: Huber R]]
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==Reference==
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<ref group="xtra">PMID:022105886</ref><references group="xtra"/>
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Arciniega, M.]]
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[[Category: Beck, P.]]
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[[Category: Gallastegui, N.]]
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[[Category: Groll, M.]]
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[[Category: Hillebrand, S.]]
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[[Category: Huber, R.]]
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[[Category: Cancer]]
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[[Category: Drug development]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Immunology]]
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[[Category: Protein degradation]]
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[[Category: Ubiquitin]]
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[[Category: Unfolded protein substrate]]
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Current revision

Proteasome in complex with hydroxyurea derivative HU10

PDB ID 3shj

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