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Cardiotoxin

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[[Image:2cdx.png|left|200px|thumb|NMR Structure of cardiotoxin CTX I from ''Naja naja atra'' [[2cdx]]]]
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<StructureSection load='2cdx' size='350' side='right' scene='42/425149/Cv/2' caption='Cardiotoxin CTX I [[2cdx]]'>
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{{STRUCTURE_2cdx| PDB=2cdx | SIZE=400| SCENE=Cardiotoxin/Cv/1 |right|CAPTION=Cardiotoxin CTX I [[2cdx]] }}
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[[Cardiotoxin]] (CTX) is a snake toxin from the Taiwan cobra ''Naja naja''. The cardiotoxin from the Malayan krait is called '''bucain'''. The images at the left and at the right correspond to one representative CTX, ''i.e.'' the NMR structure of cardiotoxin CTX I from ''Naja naja atra'' ([[2cdx]]). For toxins in Proteopedia see [[Toxins]].
 
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{{TOC limit|limit=2}}
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== Function ==
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'''Cardiotoxin''' or '''cytotoxin''' (CTX) is a snake toxin from the Taiwan cobra ''Naja naja''. The cardiotoxin from the Malayan krait is called '''bucain'''. CTX perturb the membrane structure of cells by interaction with lipids. <ref>PMID:3472200</ref> For toxins in Proteopedia see [[Toxins]].<br />
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== Relevance ==
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'''Cardiotoxin I''' causes necrosis of skeletal muscle cells.
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'''Cardiotoxin III''' induces apoptosis in K562 cells.
== 3D Structures of Cardiotoxin ==
== 3D Structures of Cardiotoxin ==
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[[Cardiotoxin 3D structures]]
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''Update June 2012''
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</StructureSection>
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[[2cdx]] - NaCTX I – NMR – ''Naja atra''<br />
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== References ==
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[[1cre]], [[1crf]] - NaCTX II – NMR<br />
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<references />
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[[2ccx]] – NmCTX II – ''Naja mossambica'' – NMR<br />
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[[1cdt]] – NmCTX II<br />
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[[1ffj]], [[1cb9]], [[1ccq]] – CTX II – ''Naja oxiana'' – NMR<br />
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[[1i02]], [[2crs]], [[2crt]] - NaCTX III – NMR<br />
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[[1xt3]], [[1h0j]] – NaCTX III<br />
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[[1kbs]], [[1kbt]] - NaCTX IV – NMR<br />
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[[1chv]], [[1cvo]] – NaCTX V – NMR<br />
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[[1kxi]] - NaCTX V<br />
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[[1ug4]] – CTX VI<br />
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[[3plc]] – β-CTX – king cobra<br />
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[[1cxn]], [[1cxo]], [[1tgx]] – γ-CTX – ''Naja nigricollis'' - NMR<br />
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[[2h8u]] – Bucain<br />
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[[2bhi]] – CTX III+sulfogalactoceramide<br />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Cardiotoxin CTX I 2cdx

Drag the structure with the mouse to rotate

References

  1. ↑ Rees B, Samama JP, Thierry JC, Gilibert M, Fischer J, Schweitz H, Lazdunski M, Moras D. Crystal structure of a snake venom cardiotoxin. Proc Natl Acad Sci U S A. 1987 May;84(10):3132-6. PMID:3472200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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