3veh

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[[Image:3veh.jpg|left|200px]]
 
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==Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT==
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The line below this paragraph, containing "STRUCTURE_3veh", creates the "Structure Box" on the page.
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<StructureSection load='3veh' size='340' side='right'caption='[[3veh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3veh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VEH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GA:3-{[(1Z)-1-CARBOXYPROP-1-EN-1-YL]OXY}-2-HYDROXYBENZOIC+ACID'>0GA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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{{STRUCTURE_3veh| PDB=3veh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3veh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veh OCA], [https://pdbe.org/3veh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3veh RCSB], [https://www.ebi.ac.uk/pdbsum/3veh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3veh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref>
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===Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT===
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==See Also==
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*[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22607697 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22607697}}
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==About this Structure==
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[[3veh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEH OCA].
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==Reference==
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<ref group="xtra">PMID:022607697</ref><references group="xtra"/>
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Baker, E N.]]
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[[Category: Baker EN]]
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[[Category: Bulloch, E M.]]
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[[Category: Bulloch EM]]
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[[Category: Chi, G.]]
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[[Category: Chi G]]
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[[Category: Johnston, J M.]]
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[[Category: Johnston JM]]
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[[Category: Lott, J S.]]
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[[Category: Lott JS]]
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[[Category: Manos-Turvey, A.]]
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[[Category: Manos-Turvey A]]
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[[Category: Payne, R J.]]
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[[Category: Payne RJ]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Isomerase]]
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[[Category: Lyase]]
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[[Category: Salicylate synthase]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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Current revision

Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT

PDB ID 3veh

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