3sdk

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[[Image:3sdk.jpg|left|200px]]
 
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==Structure of yeast 20S open-gate proteasome with Compound 34==
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The line below this paragraph, containing "STRUCTURE_3sdk", creates the "Structure Box" on the page.
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<StructureSection load='3sdk' size='340' side='right'caption='[[3sdk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sdk]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SDK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P3N:N-[(2S)-3-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)-1-({(2S)-1-[(4-METHYLBENZYL)AMINO]-1-OXO-4-PHENYLBUTAN-2-YL}AMINO)-1-OXOPROPAN-2-YL]-5-METHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>P3N</scene></td></tr>
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{{STRUCTURE_3sdk| PDB=3sdk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdk OCA], [https://pdbe.org/3sdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sdk RCSB], [https://www.ebi.ac.uk/pdbsum/3sdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sdk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSA6_YEAST PSA6_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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===Structure of yeast 20S open-gate proteasome with Compound 34===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3sdk]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDK OCA].
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[[Category: Large Structures]]
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Sintchak MD]]
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[[Category: Sintchak, M D.]]
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[[Category: 20s proteasome]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Structure of yeast 20S open-gate proteasome with Compound 34

PDB ID 3sdk

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OCA

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