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Ribosomal protein S2

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[[Image:S2.PNG|left|200px|thumb|Crystal Structure of Ribosomal protein S2 (RPS2), [[3kc4]]]]
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<StructureSection load='4v7i' size='340' side='right' caption='Ribosomal protein S2 (PDB entry [[4v7i]])' scene='41/417532/Cv/15'>
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{{STRUCTURE_3kc4| PDB=3kc4 | SIZE=400| SCENE=Ribosomal_protein_S2/Cv/1 |right|CAPTION=Ribosomal protein S2 (RPS2), [[3kc4]] }}
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== Function ==
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[[Ribosomal protein S2]] (RPS2) is one of the 21 proteins which belong to the 30S small subunit of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. Its N-terminal is rich in Arg-Gly repeats and has two RGGF copies which are believed to be associated with nuclear localization and binding to RNA. In archaea the protein is called S2P (RPS2P).
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== Relevance ==
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RPS2 is a tumor antigen recognized by antibodies. Thus its peptide can be suitable for use in immunotherapy for HLA-A26+ cancer patients<ref>PMID:12694581</ref>. RPS2 is over expressed in liver cancer<ref>PMID:12422231</ref>.
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</StructureSection>
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[[Ribosomal protein S2]] (RPS2) is one of the 22 proteins which belong to the <scene name='Ribosomal_protein_S2/Cv/12'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. Its N-terminal is rich in Arg-Gly repeats and has two RGGF copies which are believed to be associated with nuclear localization and binding to RNA. In archaea the protein is called S2P (RPS2P). The images at the left and at the right correspond to one representative RPS2, ''i.e.'' the crystal structure of Ribosomal protein S2 from ''Escherichia coli'' ([[3kc4]]).
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{{TOC limit|limit=2}}
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== 3D Structures of Ribosomal protein S2 ==
== 3D Structures of Ribosomal protein S2 ==
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''Update December 2011''
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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=== S2 ===
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[[1vi5]], [[1vi6]] – RPS2P – ''Archaeoglobus fulgidus''<br />
[[1vi5]], [[1vi6]] – RPS2P – ''Archaeoglobus fulgidus''<br />
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[[1x18]] – RPS2 + RPS7 + RPS11 + RPS18 + GTP-binding protein + RNA – ''Thermus thermophilus'' – Cryo EM<br />
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=== S2 in small ribosomal subunit ===
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[[4toi]] – RPS2/RPS1 N-terminal – ''Escherichia coli''<br />
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== References ==
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<references/>
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[[2zm6]], [[1n36]], [[1j5e]], [[3oto]] - TtRPS2 in 30S ribosomal subunit+THX+16S RRNA – ''Thermus thermophilus''<br />
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[[2vqe]], [[2vqf]], [[2uuc]], [[2e5l]], [[2uu9]], [[2uua]], [[2uub]], [[3pyn]], [[3pyq]], [[3pys]], [[3pyu]] - TtRPS2 in 30S ribosomal subunit+16S RRNA+RNA fragment<br />
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[[3kc4]] - EcRPS2 in 30S ribosomal subunit - ''Escherichia coli''<br />
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[[3i1m]], [[3i1o]], [[3df1]], [[3df3]], [[2vho]], [[2vhp]], [[2avy]], [[2aw7]], [[1pnx]] - EcRPS2 in 30S ribosomal subunit+16S RRNA<br />
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[[1i94]], [[1fka]] - TtRPS2 in 30S ribosomal subunit+16S RRNA<br />
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[[1p87]] - EcRPS2 in 30S ribosomal subunit+16S RRNA – Cryo-EM<br />
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[[3bbn]] - RPS2 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach<br />
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=== S2 in small + large ribosomal subunit ===
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[[1ml5]] - EcRPS2 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM<br />
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=== S2 in small ribosomal subunit+ chain release factor ===
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[[3mr8]], [[3ms0]] – TtRPS2 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA<br />
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[[3d5a]], [[3d5c]] - TtRPS2 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[3zvo]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3<br />
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[[2b64]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1<br />
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[[2b9m]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2<br />
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[[2x9r]], [[2x9t]], [[2wh1]], [[2wh3]] - TtRPS2 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA<br />
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[[3f1e]], [[3f1g]] - TtRPS2 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA<br />
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=== S2 in small ribosomal subunit+tRNA+mRNA ===
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[[2hgi]] - TtRPS2 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet<br />
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[[2hgp]], [[2i2p]], [[2i2u]] - TtRPS2 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2hgr]] - TtRPS2 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA<br />
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[[1yl4]] – TtRPS2 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator<br />
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[[1pns]] - EcRPS2 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA <br />
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[[1xnq]], [[1xnr]]- TtRPS2 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA<br />
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=== S2 in small ribosomal subunit+A-site tRNA ===
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[[2uxd]], [[2uxc]] - TtRPS2 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA<br />
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[[1n32]], [[1n33]] - TtRPS2 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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[[1n34]] - TtRPS2 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA<br />
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[[1xmo]], [[1xmq]] - TtRPS2 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA<br />
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[[2uxb]] - TtRPS2 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA<br />
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=== S2 in small ribosomal subunit+P-site tRNA ===
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[[3i8g]] - TtRPS2 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA<br />
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[[3i8h]], [[3i9b]], [[3i9d]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA<br />
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[[1ibk]] - TtRPS2 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA<br />
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[[2wwl]] - EcRPS2 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA <br />
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[[3i1q]] - EcRPS2 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA <br />
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[[3i1s]], [[3i1z]], [[3i21]] - EcRPS2 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA<br />
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[[2om7]] – TtRPS2+TtRPS12+TtRPL1+ P-site tRNA+16S RRNA fragment+23S RRNA fragment<br />
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=== S2 in small ribosomal subunit+A-site tRNA+P-site tRNA ===
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[[1ibl]], [[1ibm]] - TtRPS2 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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=== S2 in small ribosomal subunit+P-site tRNA+E-site tRNA ===
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[[2ow8]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA<br />
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[[2b9o]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA<br />
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[[2qnh]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[2wdg]], [[2wdh]], [[2wdk]], [[2wdm]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe<br />
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=== S2 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA ===
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[[2gy9]], [[2gyb]] - EcRPS2 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM<br />
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[[1jgo]], [[1jgp]], [[1jgq]], [[1gix]] - TtRPS2 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA<br />
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[[3e1a]], [[3e1c]] - EcRPS2 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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=== S2 in small ribosomal subunit + antibiotics ===
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[[1i95]], [[1i97]], [[2hhh]], [[2f4v]], [[3oge]], [[3ogy]], [[3ohc]], [[3ohd]], [[3ohy]], [[3oi0]], [[3oi2]], [[3oi4]] - TtRPS2 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[1hnw]], [[1hnx]], [[1hnz]], [[1fjg]] - TtRPS2 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic<br />
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[[2qbb]], [[2qb9]], [[1vs5]], [[1vs7]], [[2qan]], [[2qal]], [[2quo]], [[2qow]], [[2qoy]], [[2qp0]], [[2z4k]], [[2z4m]], [[3oaq]], [[3oar]], [[3ofa]], [[3ofb]], [[3ofo]], [[3ofp]], [[3ofx]], [[3ofyp]], [[3or9]], [[3ora]] - EcRPS2 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[2j00]], [[2j02]] - TtRPS2 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA<br />
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[[3knj]], [[3knh]] - TtRPS2 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin<br />
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[[3knl]], [[3knm]], [[3knn]], [[3kno]] - TtRPS2 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin<br />
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=== S2 in small ribosomal subunit + ribosome recycling factor ===
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[[2qbd]], [[2qbf]] - EcRPS2 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor<br />
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[[3r8n]], [[3r8o]] - EcRPS2 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA<br />
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[[2qbh]], [[2qbj]] - EcRPS2 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin<br />
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[[2v46]], [[2v48]] - TtRPS2 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet<br />
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=== S2 in small ribosomal subunit + elongation factor ===
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[[2wri]], [[2wrk]] - TtRPS2 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G<br />
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[[2wrn]], [[2wrq]] - TtRPS2 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4<br />
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[[3fic]] - TtRPS2 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A<br />
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[[2y0u]], [[2y0w]], [[2y0y]], [[2y10]], [[2y12]], [[2y14]], [[2y16]], [[2y18]] - TtRPS2 in30S subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU<br />
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[[3fih]] - EcRPS2 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU<br />
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[[3izv]] - EcRPS2 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU<br />
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[[3izw]] - EcRPS2 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU<br />
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[[3huw]], [[3huy]] - TtRPS2 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P<br />
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=== S2 in small ribosomal subunit + translation initiation factor ===
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[[1i96]] - TtRPS2 in 30S ribosomal subunit+THX+IF3+16S RRNA<br />
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[[1hr0]] - TtRPS2 in 30S ribosomal subunit+THX+IF+16S RRNA<br />
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=== S2 in small ribosomal subunit + various proteins ===
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[[3kiq]], [[3kis]], [[3kiu]], [[3kix]] - TtRPS2 in 30S ribosomal subunit+toxin RelE+16S RRNA<br />
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[[1voq]], [[1vos]] , [[1vov]], [[1vox]], [[1voz]] - EcRPS2 in 30S ribosomal subunit+protein Y+16S RRNA<br />
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[[1x18]] – TtRPS2+TtRPS7+TtRPS11+TtRPS18+GTP-binding protein ERA+RNA fragments<br />
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[[2ykr]] - EcRPS2 + 16S RRNA + GMPPNP + GTPase RSGA<br />
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[[4a2i]] - EcRPS2 + 16S RRNA + GTPase RSGA – Cryo EM
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===S2 in small 40S ribosomal subunit===
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[[3jyv]] - TlRPS2 in 40S ribosomal subunit+RACK1+S19E+P-site tRNA – ''Thermomyces lanuginosus''<br />
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[[2xzm]], [[2xzn]] - RPS2 in 40S ribosomal subunit+RACK1 – ''Tetrahymena thermophila''<br />
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[[1s1h]] - yRPS2 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast<br />
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[[3izb]] - yRPS2 in 40S ribosomal subunit+ RACK1 – Cryo-EM<br />
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[[3o2z]], [[3o30]] - yRPS2 in 40S ribosomal subunit+ RACK1<br />
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[[3iz6]] - RPS2 in 40S ribosomal subunit+RACK1 - wheat
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein S2 (PDB entry 4v7i)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein S2

Updated on 31-December-2017

1vi5, 1vi6 – RPS2P – Archaeoglobus fulgidus
1x18 – RPS2 + RPS7 + RPS11 + RPS18 + GTP-binding protein + RNA – Thermus thermophilus – Cryo EM
4toi – RPS2/RPS1 N-terminal – Escherichia coli

References

  1. ↑ Koga M, Shichijo S, Yamada A, Ashihara J, Sawamizu H, Kusukawa J, Itoh K. Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. Tissue Antigens. 2003 Feb;61(2):136-45. PMID:12694581
  2. ↑ Kowalczyk P, Woszczynski M, Ostrowski J. Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro. Acta Biochim Pol. 2002;49(3):615-24. PMID:12422231 doi:http://dx.doi.org/024903615

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Wayne Decatur, Joel L. Sussman

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