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3c91
From Proteopedia
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| - | [[Image:3c91.png|left|200px]] | ||
| - | + | ==Thermoplasma acidophilum 20S proteasome with an open gate== | |
| - | + | <SX load='3c91' size='340' side='right' viewer='molstar' caption='[[3c91]], [[Resolution|resolution]] 6.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3c91]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C91 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c91 OCA], [https://pdbe.org/3c91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c91 RCSB], [https://www.ebi.ac.uk/pdbsum/3c91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c91 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[3c91]] is a 28 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PSA_THEAC PSA_THEAC] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.<ref>PMID:8999862</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c91_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c91 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Proteasome|Proteasome]] | + | *[[Proteasome 3D structures|Proteasome 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </SX> |
| + | [[Category: Large Structures]] | ||
[[Category: Thermoplasma acidophilum]] | [[Category: Thermoplasma acidophilum]] | ||
| - | [[Category: Chang | + | [[Category: Chang SC]] |
| - | [[Category: Cheng | + | [[Category: Cheng Y]] |
| - | [[Category: Goldberg | + | [[Category: Goldberg AL]] |
| - | [[Category: Rabl | + | [[Category: Rabl J]] |
| - | [[Category: Smith | + | [[Category: Smith DM]] |
| - | [[Category: Yu | + | [[Category: Yu Y]] |
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Current revision
Thermoplasma acidophilum 20S proteasome with an open gate
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