1kcf
From Proteopedia
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| - | [[Image:1kcf.png|left|200px]] | ||
| - | + | ==Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2== | |
| - | + | <StructureSection load='1kcf' size='340' side='right'caption='[[1kcf]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1kcf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KCF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcf OCA], [https://pdbe.org/1kcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kcf RCSB], [https://www.ebi.ac.uk/pdbsum/1kcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kcf ProSAT]</span></td></tr> |
| - | [[1kcf]] is a 2 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CCE1_SCHPO CCE1_SCHPO] Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' and 5'-TT-3' sequences.<ref>PMID:9343409</ref> <ref>PMID:10954073</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/1kcf_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kcf ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Resolvase|Resolvase]] | *[[Resolvase|Resolvase]] | ||
| - | + | *[[Resolvase 3D structures|Resolvase 3D structures]] | |
| - | == | + | == References == |
| - | < | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Schizosaccharomyces pombe]] | [[Category: Schizosaccharomyces pombe]] | ||
| - | [[Category: Barrett | + | [[Category: Barrett TE]] |
| - | [[Category: Ceschini | + | [[Category: Ceschini S]] |
| - | [[Category: Keeley | + | [[Category: Keeley A]] |
| - | [[Category: McAlister | + | [[Category: McAlister MSB]] |
| - | [[Category: Oram | + | [[Category: Oram M]] |
| - | [[Category: Pearl | + | [[Category: Pearl LH]] |
| - | [[Category: Phelan | + | [[Category: Phelan J]] |
| - | [[Category: Tsaneva | + | [[Category: Tsaneva IR]] |
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Current revision
Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2
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