1yx5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1yx5" [edit=sysop:move=sysop])
Current revision (08:07, 15 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1yx5.png|left|200px]]
 
-
{{STRUCTURE_1yx5| PDB=1yx5 | SCENE= }}
+
==Solution Structure of S5a UIM-1/Ubiquitin Complex==
 +
<StructureSection load='1yx5' size='340' side='right'caption='[[1yx5]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1yx5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YX5 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yx5 OCA], [https://pdbe.org/1yx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yx5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yx5 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PSMD4_HUMAN PSMD4_HUMAN] Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/1yx5_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yx5 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Ubiquitin is a key regulatory molecule in diverse cellular events. How cells determine the outcome of ubiquitylation remains unclear; however, a likely determinant is the specificity of ubiquitin receptor proteins for polyubiquitin chains of certain length and linkage. Proteasome subunit S5a contains two ubiquitin-interacting motifs (UIMs) through which it recruits ubiquitylated substrates to the proteasome for their degradation. Here, we report the structure of S5a (196-306) alone and complexed with two monoubiquitin molecules. This construct contains the two UIMs of S5a and we reveal their different ubiquitin-binding mechanisms and provide a rationale for their unique specificities for different ubiquitin-like domains. Furthermore, we provide direct evidence that S5a (196-306) binds either K63-linked or K48-linked polyubiquitin, and in both cases prefers longer chains. On the basis of these results we present a model for how S5a and other ubiquitin-binding proteins recognize polyubiquitin.
-
===Solution Structure of S5a UIM-1/Ubiquitin Complex===
+
Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition.,Wang Q, Young P, Walters KJ J Mol Biol. 2005 May 6;348(3):727-39. PMID:15826667<ref>PMID:15826667</ref>
-
{{ABSTRACT_PUBMED_15826667}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1yx5" style="background-color:#fffaf0;"></div>
-
[[1yx5]] is a 2 chain structure of [[Proteasome]] and [[Ubiquitin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX5 OCA].
+
==See Also==
==See Also==
-
*[[Proteasome|Proteasome]]
+
*[[Proteasome 3D structures|Proteasome 3D structures]]
-
*[[Ubiquitin|Ubiquitin]]
+
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:015826667</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Walters, K J.]]
+
[[Category: Large Structures]]
-
[[Category: Wang, Q.]]
+
[[Category: Walters KJ]]
-
[[Category: Young, P.]]
+
[[Category: Wang Q]]
-
[[Category: Hydrolase]]
+
[[Category: Young P]]
-
[[Category: Polyubiquitin]]
+
-
[[Category: Proteasome]]
+
-
[[Category: S5a]]
+
-
[[Category: Uim]]
+

Current revision

Solution Structure of S5a UIM-1/Ubiquitin Complex

PDB ID 1yx5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yx5"
Personal tools