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3h4p

From Proteopedia

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[[Image:3h4p.png|left|200px]]
 
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{{STRUCTURE_3h4p| PDB=3h4p | SCENE= }}
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==Proteasome 20S core particle from Methanocaldococcus jannaschii==
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<StructureSection load='3h4p' size='340' side='right'caption='[[3h4p]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
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===Proteasome 20S core particle from Methanocaldococcus jannaschii===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3h4p]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H4P FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19481527}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h4p OCA], [https://pdbe.org/3h4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h4p RCSB], [https://www.ebi.ac.uk/pdbsum/3h4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h4p ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3h4p]] is a 28 chain structure of [[Proteasome]] with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H4P OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PSA_METJA PSA_METJA] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.jannaschii proteasome is able to cleave oligopeptides after Glu, Asp, Tyr, Phe, Trp, slightly after Arg, but not after Ala. Thus, displays caspase-like and chymotrypsin-like activities and low level of trypsin-like activity.[HAMAP-Rule:MF_00289]<ref>PMID:10692374</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/3h4p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h4p ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Proteasome|Proteasome]]
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019481527</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Finley D]]
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[[Category: Finley, D.]]
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[[Category: Hu M]]
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[[Category: Hu, M.]]
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[[Category: Jeffrey PD]]
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[[Category: Jeffrey, P D.]]
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[[Category: Shi Y]]
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[[Category: Shi, Y.]]
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[[Category: Tian G]]
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[[Category: Tian, G.]]
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[[Category: Zhang F]]
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[[Category: Zhang, F.]]
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[[Category: Zhang P]]
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[[Category: Zhang, P.]]
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[[Category: 20]]
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[[Category: Core particle]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Proteasome]]
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[[Category: Threonine protease]]
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Current revision

Proteasome 20S core particle from Methanocaldococcus jannaschii

PDB ID 3h4p

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