2fm9
From Proteopedia
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| - | [[Image:2fm9.png|left|200px]] | ||
| - | + | ==Structure of Salmonella SipA residues 48-264== | |
| - | + | <StructureSection load='2fm9' size='340' side='right'caption='[[2fm9]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2fm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm9 OCA], [https://pdbe.org/2fm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm9 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm9 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2fm9]] is a 1 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/SIPA_SALTY SIPA_SALTY] Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments.<ref>PMID:10092234</ref> <ref>PMID:14992720</ref> | |
| - | == | + | == References == |
| - | < | + | <references/> |
| - | [ | + | __TOC__ |
| - | [ | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | |
| - | [ | + | [[Category: Lilic M]] |
| - | [[Category: | + | [[Category: Stebbins CE]] |
| - | [[Category: Salmonella]] | + | [[Category: Vujanac M]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | [[Category: | + | |
Current revision
Structure of Salmonella SipA residues 48-264
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