Enolase multiple sequence alignment
From Proteopedia
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| + | This page is a supplement to [[Introduction to Evolutionary Conservation]]. The portion of the multiple sequence alignment (MSA) below with <span style="background:pink;"> a pink background </span> is enlarged on that page. | ||
| + | ---- | ||
Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis. | Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis. | ||
| - | Key: IDENTICAL(*) | + | Key: '''IDENTICAL'''(*) SIMILAR(.) different |
| - | + | ||
| + | Consensus Percentage is set to 100%. | ||
| + | ---- | ||
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; | <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; | ||
mso-bidi-font-family:"Courier New"'> 1 ENO_DROME| | mso-bidi-font-family:"Courier New"'> 1 ENO_DROME| | ||
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EVytetgafg rAlv<b>PSGAST</b> 43<br> | EVytetgafg rAlv<b>PSGAST</b> 43<br> | ||
6 4ENL Yeast| Saccharomyces cerevisiae ---------a VskVyA<b>R</b>sVy | 6 4ENL Yeast| Saccharomyces cerevisiae ---------a VskVyA<b>R</b>sVy | ||
| - | <b>DSRGNPTVE</b>v ELtt-ekgvf rSiv<b>PSGAST</b> 40 | + | <b>DSRGNPTVE</b>v ELtt-ekgvf rSiv<b>PSGAST</b> 40</span></p> |
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6 4ENL Yeast| Saccharomyces cerevisiae <b>G</b>vh<b>EA</b>L<b>E</b>m<b>RD</b> | 6 4ENL Yeast| Saccharomyces cerevisiae <b>G</b>vh<b>EA</b>L<b>E</b>m<b>RD</b> | ||
gD<b>K</b>skWm<b>GK</b>G <b>V</b>lh<b>AV</b>knV<b>N</b>d vIapafVkan idvsd<b>Q</b>kaV<b>D</b> | gD<b>K</b>skWm<b>GK</b>G <b>V</b>lh<b>AV</b>knV<b>N</b>d vIapafVkan idvsd<b>Q</b>kaV<b>D</b> | ||
| - | 90 | + | 90</span></p> |
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6 4ENL Yeast| Saccharomyces cerevisiae dfl<b>I</b>sl<b>DGT</b>a | 6 4ENL Yeast| Saccharomyces cerevisiae dfl<b>I</b>sl<b>DGT</b>a | ||
<b>NK</b>SKl<b>GANAI</b> <b>L</b>G<b>VS</b>l<b>A</b>asR<b>A</b> A<b>A</b>aeknv<b>PLY</b> | <b>NK</b>SKl<b>GANAI</b> <b>L</b>G<b>VS</b>l<b>A</b>asR<b>A</b> A<b>A</b>aeknv<b>PLY</b> | ||
| - | khLAdlsksk 140 | + | khLAdlsksk 140</span></p> |
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6 4ENL Yeast| Saccharomyces cerevisiae tspyvl<b>PVP</b>f | 6 4ENL Yeast| Saccharomyces cerevisiae tspyvl<b>PVP</b>f | ||
l<b>N</b>VL<b>NGG</b>s<b>HA</b> ggaLal<b>QEFM</b> <b>I</b>a<b>P</b>t<b>GA</b>ktfa | l<b>N</b>VL<b>NGG</b>s<b>HA</b> ggaLal<b>QEFM</b> <b>I</b>a<b>P</b>t<b>GA</b>ktfa | ||
| - | <b>EA</b>lRi<b>G</b>SeVY 190 | + | <b>EA</b>lRi<b>G</b>SeVY 190</span></p> |
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style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: | style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: | ||
yes"> </span>**** * * **<span style="mso-spacerun: | yes"> </span>**** * * **<span style="mso-spacerun: | ||
| - | yes"> </span>** . *. .. | + | yes"> </span>** . *. ..</span></p> |
<span style='font-size:10.0pt;font-family:"Courier New";mso-fareast-font-family: | <span style='font-size:10.0pt;font-family:"Courier New";mso-fareast-font-family: | ||
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ne<b>E</b>A<b>L</b>qtIve AIek<b>AG</b>fkpg 234<br> | ne<b>E</b>A<b>L</b>qtIve AIek<b>AG</b>fkpg 234<br> | ||
6 4ENL Yeast| Saccharomyces cerevisiae <b>H</b>n<b>L</b>ksLtkkR | 6 4ENL Yeast| Saccharomyces cerevisiae <b>H</b>n<b>L</b>ksLtkkR | ||
| - | ygasagn<b>VGD</b> <b>EGG</b>v<b>AP</b>nIqt ae<b>E</b>A<b>L</b>dlIvd AIka<b>AG</b> | + | ygasagn<b>VGD</b> <b>EGG</b>v<b>AP</b>nIqt ae<b>E</b>A<b>L</b>dlIvd AIka<b>AG</b>---- 238</span></p> |
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style='font-size:10.0pt;font-family:"Courier New";mso-bidi-font-family:"Courier New"'><span | style='font-size:10.0pt;font-family:"Courier New";mso-bidi-font-family:"Courier New"'><span | ||
style="mso-spacerun: | style="mso-spacerun: | ||
yes"> | yes"> | ||
</span><span style="mso-spacerun: | </span><span style="mso-spacerun: | ||
| - | yes"> </span>* | + | yes"> </span>**<span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: |
| - | *<span style="mso-spacerun: yes"> </span>.<span style="mso-spacerun: | + | |
yes"> </span>.<span style="mso-spacerun: | yes"> </span>.<span style="mso-spacerun: | ||
yes"> </span>*** *** ** .<span | yes"> </span>*** *** ** .<span | ||
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<span style="mso-spacerun: | <span style="mso-spacerun: | ||
yes"> | yes"> | ||
| - | </span> | + | </span> |
| - | 1 ENO_DROME| Drosophila melanogaster gkIeiGm<b>D</b>v<b>A</b> | + | |
| - | A<b>SEF</b>Yk--d<b>G</b> q<b>Y</b>dLdfknek sdksqwlpad klanlykefi 285<br> | + | <br> |
| + | 1 ENO_DROME| Drosophila melanogaster <span style="background:pink;"> gkIeiGm<b>D</b>v<b>A</b> | ||
| + | A<b>SEF</b>Yk--d<b>G</b></span> q<b>Y</b>dLdfknek sdksqwlpad klanlykefi 285<br> | ||
2 ENOA_HUMAN| | 2 ENOA_HUMAN| | ||
| - | Homo sapiens dkVviGm<b>D</b>v<b>A</b> A<b>SEF</b>Fr--s<b>G</b> k<b>Y</b>dLdfksp- | + | Homo sapiens <span style="background:pink;"> dkVviGm<b>D</b>v<b>A</b> A<b>SEF</b>Fr--s<b>G</b></span> k<b>Y</b>dLdfksp- |
ddpsryispd qladlyksfi 283<br> | ddpsryispd qladlyksfi 283<br> | ||
| - | 3 ENO_METJA| Methanococcus janaschii deVvfAl<b>D</b>a<b>A</b> | + | 3 ENO_METJA| Methanococcus janaschii <span style="background:pink;"> deVvfAl<b>D</b>a<b>A</b> |
| - | A<b>SEF</b>Yk--d<b>G</b> y<b>Y</b>yVegkk-- ------ltre elldyykalv 280<br> | + | A<b>SEF</b>Yk--d<b>G</b></span> y<b>Y</b>yVegkk-- ------ltre elldyykalv 280<br> |
4 ENO_ECOLI| | 4 ENO_ECOLI| | ||
| - | Escherichia coli kdItlAm<b>D</b>c<b>A</b> A<b>SEF</b>Yk--d<b>G</b> k<b>Y</b>vLagegn- | + | Escherichia coli <span style="background:pink;"> kdItlAm<b>D</b>c<b>A</b> A<b>SEF</b>Yk--d<b>G</b></span> k<b>Y</b>vLagegn- |
| - | ----kaftse efthfleelt 280<br> | + | ----kaftse efthfleelt 280<br> |
5 ENO_BACSU| | 5 ENO_BACSU| | ||
| - | Bacillus subtilis eeVklAm<b>D</b>a<b>A</b> S<b>SEF</b>Ynked<b>G</b> k<b>Y</b>hLsgeg-- | + | Bacillus subtilis <span style="background:pink;"> eeVklAm<b>D</b>a<b>A</b> S<b>SEF</b>Ynked<b>G</b></span> k<b>Y</b>hLsgeg-- |
| - | ----vvktsa emvdwyeelv 278<br> | + | ----vvktsa emvdwyeelv 278<br> |
| - | 6 4ENL Yeast| Saccharomyces cerevisiae gkVkiGl<b>D</b>c<b>A</b> | + | 6 4ENL Yeast| Saccharomyces cerevisiae <span style="background:pink;"> gkVkiGl<b>D</b>c<b>A</b> |
| - | S<b>SEF</b>Fk--d<b>G</b> k<b>Y</b>dLdfknpn sdkskwltgp qladlyhslm 286 | + | S<b>SEF</b>Fk--d<b>G</b></span> k<b>Y</b>dLdfknpn sdkskwltgp qladlyhslm 286</span></p> |
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<span style="mso-spacerun: | <span style="mso-spacerun: | ||
yes"> | yes"> | ||
| - | </span> | + | </span><br> |
1 ENO_DROME| Drosophila melanogaster kdF<b>P</b>IV<b>SIED</b> | 1 ENO_DROME| Drosophila melanogaster kdF<b>P</b>IV<b>SIED</b> | ||
pfdqdhWeAw snltgctd-- I<b>Q</b>I<b>V</b>G<b>DDL</b>t<b>V</b> <b>TN</b>pkrIatAV | pfdqdhWeAw snltgctd-- I<b>Q</b>I<b>V</b>G<b>DDL</b>t<b>V</b> <b>TN</b>pkrIatAV | ||
| Line 218: | Line 209: | ||
6 4ENL Yeast| Saccharomyces cerevisiae krY<b>P</b>IV<b>SIED</b> | 6 4ENL Yeast| Saccharomyces cerevisiae krY<b>P</b>IV<b>SIED</b> | ||
pfaeddWeAw shffktag-- I<b>Q</b>I<b>V</b>A<b>DDL</b>t<b>V</b> <b>TN</b>pkrIatAI | pfaeddWeAw shffktag-- I<b>Q</b>I<b>V</b>A<b>DDL</b>t<b>V</b> <b>TN</b>pkrIatAI | ||
| - | 334 | + | 334</span></p> |
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6 4ENL Yeast| Saccharomyces cerevisiae ekkaadaL<b>L</b>L | 6 4ENL Yeast| Saccharomyces cerevisiae ekkaadaL<b>L</b>L | ||
<b>K</b>v<b>NQIG</b>tLs<b>E</b> sik<b>A</b>aqdSfa a<b>G</b>WgvmV<b>SHR</b> <b>SGETED</b>tf<b>I</b>A | <b>K</b>v<b>NQIG</b>tLs<b>E</b> sik<b>A</b>aqdSfa a<b>G</b>WgvmV<b>SHR</b> <b>SGETED</b>tf<b>I</b>A | ||
| - | 384 | + | 384</span></p> |
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6 4ENL Yeast| Saccharomyces cerevisiae <b>D</b>Lv<b>V</b>Glrt<b>GQ</b> | 6 4ENL Yeast| Saccharomyces cerevisiae <b>D</b>Lv<b>V</b>Glrt<b>GQ</b> | ||
<b>IKTG</b>Apa<b>R</b>sE <b>R</b>l<b>AK</b>l<b>NQ</b>LL<b>R</b> <b>IE</b>eeLGdnav | <b>IKTG</b>Apa<b>R</b>sE <b>R</b>l<b>AK</b>l<b>NQ</b>LL<b>R</b> <b>IE</b>eeLGdnav | ||
| - | Fa<b>G</b>enfhhgd 434 | + | Fa<b>G</b>enfhhgd 434</span></p> |
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style="mso-spacerun: yes"> </span>* . * ** **..* **<span | style="mso-spacerun: yes"> </span>* . * ** **..* **<span | ||
style="mso-spacerun: yes"> </span>..<span style="mso-spacerun: | style="mso-spacerun: yes"> </span>..<span style="mso-spacerun: | ||
| - | yes"> </span>. * | + | yes"> </span>. *</span></p> |
<span style='font-size:10.0pt;font-family:"Courier New";mso-fareast-font-family: | <span style='font-size:10.0pt;font-family:"Courier New";mso-fareast-font-family: | ||
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Bacillus subtilis nk 430<br> | Bacillus subtilis nk 430<br> | ||
6 4ENL Yeast| Saccharomyces cerevisiae kl 436<br> | 6 4ENL Yeast| Saccharomyces cerevisiae kl 436<br> | ||
| + | </span></p> | ||
| + | ---- | ||
| + | Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%: | ||
| + | 33% (142) IDENTICAL(*) 16% (68) SIMILAR(.) 52% (226) different | ||
| - | + | Definitions of SIMILAR groups of amino acids:<pre> | |
| - | + | ILV Ile Leu Val hydrophobic, aliphatic / medium-sized side-chain | |
| - | + | FWY Phe Trp Tyr hydrophobic, aromatic / large side-chain (Tyr polar) | |
| - | + | KRH Lys Arg His + charge | |
| - | + | DE Asp Glu - charge | |
| - | Definitions of SIMILAR groups of amino acids: | + | GAS Gly Ala Ser small |
| - | ILV | + | P Pro helix breaking |
| - | FWY | + | C Cys disulfide-forming |
| - | KRH | + | |
| - | DE | + | |
| - | GAS | + | |
| - | P | + | |
| - | C | + | |
TNQM Thr Asn Gln Met polar (except Met) | TNQM Thr Asn Gln Met polar (except Met) | ||
| + | </pre> | ||
Current revision
This page is a supplement to Introduction to Evolutionary Conservation. The portion of the multiple sequence alignment (MSA) below with a pink background is enlarged on that page.
Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis.
Key: IDENTICAL(*) SIMILAR(.) different
Consensus Percentage is set to 100%.
1 ENO_DROME|
Drosophila melanogaster --------mt IkaIkARqIy DSRGNPTVEv
DLtt-elglf rAavPSGAST 41
2 ENOA_HUMAN|
Homo sapiens ---------s IlkIhAReIf DSRGNPTVEv DLft-skglf
rAavPSGAST 40
3 ENO_METJA| Methanococcus janaschii
mlynmderfe IkdIvAReVi DSRGNPTVEv EVitkgngyg sAivPSGAST
50
4 ENO_ECOLI|
Escherichia coli --------sk IvkIiGReIi DSRGNPTVEa
EVhleggfvg mAaaPSGAST 42
5 ENO_BACSU|
Bacillus subtilis -------mpy IvdVyAReVl DSRGNPTVEv
EVytetgafg rAlvPSGAST 43
6 4ENL Yeast| Saccharomyces cerevisiae ---------a VskVyARsVy
DSRGNPTVEv ELtt-ekgvf rSivPSGAST 40
. . .* . *********
..
. ******
1 ENO_DROME| Drosophila melanogaster GvhEALElRD
nDKanYhGKS VlkAVghVNd tLgpelIkan ldvvdQasID
91
2 ENOA_HUMAN|
Homo sapiens GiyEALElRD nDKtrYmGKG
VskAVehINk tIapalVskk lnvteQekID 90
3 ENO_METJA| Methanococcus janaschii GthEALElRD
kEK-rFgGKG VlmAVenVNs iIrpeiLg-- ydarmQreID
97
4 ENO_ECOLI|
Escherichia coli GsrEALElRD gDKsrFlGKG
VtkAVaaVNg pIaqalIg-- kdakdQagID 90
5 ENO_BACSU| Bacillus
subtilis GeyEAVElRD gDKdrYlGKG VltAVnnVNe
iIapelLg-- fdvteQnaID 91
6 4ENL Yeast| Saccharomyces cerevisiae GvhEALEmRD
gDKskWmGKG VlhAVknVNd vIapafVkan idvsdQkaVD
90
* **.* ** .* . **. * ** .* . . * .*
1 ENO_DROME| Drosophila melanogaster nfmIklDGTe
NKSKfGANAI LGVSlAvaKA GAakkgvPLY
khIAdlagn- 140
2 ENOA_HUMAN|
Homo sapiens klmIemDGTe NKSKfGANAI LGVSlAvcKA
GAvekgvPLY rhIAdlagn- 139
3 ENO_METJA| Methanococcus janaschii timIelDGTp
NKSRlGANAI LAVSlAvaKA AAatakiPLY
kyLGgfn--- 144
4 ENO_ECOLI|
Escherichia coli kimIdlDGTe NKSKfGANAI LAVSlAnaKA
AAaakgmPLY ehIAelngt- 139
5 ENO_BACSU|
Bacillus subtilis qllIelDGTe NKGKlGANAI LGVSmAcaRA
AAdflqiPLY qyLGgfn--- 138
6 4ENL Yeast| Saccharomyces cerevisiae dflIslDGTa
NKSKlGANAI LGVSlAasRA AAaeknvPLY
khLAdlsksk 140
* *** **.. ***** *.** * .* .* *** .
1 ENO_DROME| Drosophila melanogaster -keiilPVPa
fNVINGGsHA gnkLamQEFM IlPtGAtsft
EAmKmGSeVY 189
2 ENOA_HUMAN|
Homo sapiens -sevilPVPa fNVINGGsHA gnkLamQEFM
IlPvGAanfr EAmRiGAeVY 188
3 ENO_METJA| Methanococcus janaschii --syvmPVPm
mNVINGGkHA gndLdlQEFM ImPvGAtsis
EAvRmGSeVY 192
4 ENO_ECOLI|
Escherichia coli pgkysmPVPm mNIINGGeHA dnnVdiQEFM
IqPvGAktvk EAiRmGSeVF 189
5 ENO_BACSU|
Bacillus subtilis --sktlPVPm mNIVNGGeHA
dnnVdiQEFM ImPvGApnfr EAlRmGAqIF 186
6 4ENL Yeast| Saccharomyces cerevisiae tspyvlPVPf
lNVLNGGsHA ggaLalQEFM IaPtGAktfa
EAlRiGSeVY 190
*** *..*** ** . **** * * ** ** . *. ..
1 ENO_DROME|
Drosophila melanogaster HhLknVikaK fgldataVGD EGGfAPnIqs
nkEALnlIsd AIakAGyt-- 237
2 ENOA_HUMAN|
Homo sapiens HnLknVikeK ygkdatnVGD EGGfAPnIle
nkEGLelLkt AIgkAGyt-- 236
3 ENO_METJA| Methanococcus janaschii HvLknVileK
ygknavnVGD EGGfAPpLkt srEALdlLte SVkkAGye--
240
4 ENO_ECOLI|
Escherichia coli HhLakVlkaK g--mntaVGD EGGyAPnLgs
naEALavIae AVkaAGyelg 237
5 ENO_BACSU|
Bacillus subtilis HsLksVlsaK g--lntaVGD EGGfAPnLgs
neEALqtIve AIekAGfkpg 234
6 4ENL Yeast| Saccharomyces cerevisiae HnLksLtkkR
ygasagnVGD EGGvAPnIqt aeEALdlIvd AIkaAG---- 238
** . . *** *** ** . *.* . .. **
1 ENO_DROME| Drosophila melanogaster gkIeiGmDvA
ASEFYk--dG qYdLdfknek sdksqwlpad klanlykefi 285
2 ENOA_HUMAN|
Homo sapiens dkVviGmDvA ASEFFr--sG kYdLdfksp-
ddpsryispd qladlyksfi 283
3 ENO_METJA| Methanococcus janaschii deVvfAlDaA
ASEFYk--dG yYyVegkk-- ------ltre elldyykalv 280
4 ENO_ECOLI|
Escherichia coli kdItlAmDcA ASEFYk--dG kYvLagegn-
----kaftse efthfleelt 280
5 ENO_BACSU|
Bacillus subtilis eeVklAmDaA SSEFYnkedG kYhLsgeg--
----vvktsa emvdwyeelv 278
6 4ENL Yeast| Saccharomyces cerevisiae gkVkiGlDcA
SSEFFk--dG kYdLdfknpn sdkskwltgp qladlyhslm 286
. . * * .***. * *
.
1 ENO_DROME| Drosophila melanogaster kdFPIVSIED
pfdqdhWeAw snltgctd-- IQIVGDDLtV TNpkrIatAV
333
2 ENOA_HUMAN|
Homo sapiens kdYPVVSIED pfdqddWgAw qkftasag-- IQVVGDDLtV
TNpkrIakAV 331
3 ENO_METJA| Methanococcus janaschii deYPIVSIED
pfheedFeGf amitkeld-- IQIVGDDLfV TNverLrkGI
328
4 ENO_ECOLI|
Escherichia coli kqYPIVSIED gldesdWdGf ayqtkvlgdk IQLVGDDLfV
TNtkiLkeGI 330
5 ENO_BACSU|
Bacillus subtilis skYPIISIED gldendWeGh kllterlgkk VQLVGDDLfV
TNtkkLseGI 328
6 4ENL Yeast| Saccharomyces cerevisiae krYPIVSIED
pfaeddWeAw shffktag-- IQIVADDLtV TNpkrIatAI
334
.*..**** . .
.*.*.*** * ** . ..
1 ENO_DROME| Drosophila melanogaster
ekkacncLLL KvNQIGtVtE siaAhllAkk nGWgtmVSHR
SGETEDsfIG 383
2 ENOA_HUMAN|
Homo sapiens nekscncLLL KvNQIGsVtE slqAcklAqa
nGWgvmVSHR SGETEDtfIA 381
3 ENO_METJA| Methanococcus janaschii
emkaanaLLL KvNQIGtLsE avdAaqlAfr nGYgvvVSHR
SGETEDttIA 378
4 ENO_ECOLI|
Escherichia coli ekgiansILI KfNQIGsLtE tlaAikmAkd
aGYtavISHR SGETEDatIA 380
5 ENO_BACSU|
Bacillus subtilis kngvgnsILI KvNQIGtLtE tfdAiemAkr
aGYtavISHR SGETEDstIA 378
6 4ENL Yeast| Saccharomyces cerevisiae ekkaadaLLL
KvNQIGtLsE sikAaqdSfa aGWgvmVSHR SGETEDtfIA
384
.*. . **** . *
* . *. .*** ****** *.
1 ENO_DROME| Drosophila melanogaster DLvVGlstGQ
IKTGApcRsE RlAKyNQILR IEeeIGagvk
FaGksfgkpq 433
2 ENOA_HUMAN|
Homo sapiens DLvVGlctGQ IKTGApcRsE RlAKyNQLLR
IEeeLGskak FaGrnfrnpl 431
3 ENO_METJA| Methanococcus janaschii DLsVAlnsGQ
IKTGApaRgE RtAKyNQLIR IEqeLG-lsk
YaGrnfrcpf 427
4 ENO_ECOLI|
Escherichia coli DLaVGtaaGQ IKTGSmsRsD
RvAKyNQLIR IEeaLGekap YnGrkeikgq 430
5 ENO_BACSU|
Bacillus subtilis DIaVAtnaGQ IKTGApsRtD
RvAKyNQLLR IEdqLAetaq YhGinsfynl 428
6 4ENL Yeast| Saccharomyces cerevisiae DLvVGlrtGQ
IKTGApaRsE RlAKlNQLLR IEeeLGdnav
FaGenfhhgd 434
*. *. ** ****. * . * ** **..* ** .. . *
1 ENO_DROME|
Drosophila melanogaster -- 433
2 ENOA_HUMAN|
Homo sapiens ak 433
3 ENO_METJA| Methanococcus janaschii -- 427
4 ENO_ECOLI|
Escherichia coli a- 431
5 ENO_BACSU|
Bacillus subtilis nk 430
6 4ENL Yeast| Saccharomyces cerevisiae kl 436
Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%:
33% (142) IDENTICAL(*) 16% (68) SIMILAR(.) 52% (226) different
Definitions of SIMILAR groups of amino acids:ILV Ile Leu Val hydrophobic, aliphatic / medium-sized side-chain FWY Phe Trp Tyr hydrophobic, aromatic / large side-chain (Tyr polar) KRH Lys Arg His + charge DE Asp Glu - charge GAS Gly Ala Ser small P Pro helix breaking C Cys disulfide-forming TNQM Thr Asn Gln Met polar (except Met)
