3shj
From Proteopedia
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| - | [[Image:3shj.png|left|200px]] | ||
| - | + | ==Proteasome in complex with hydroxyurea derivative HU10== | |
| - | + | <StructureSection load='3shj' size='340' side='right'caption='[[3shj]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3shj]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H10:1-HYDROXY-1-[(2R)-4-{3-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YLOXY]PHENYL}BUT-3-YN-2-YL]UREA'>H10</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3shj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shj OCA], [https://pdbe.org/3shj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3shj RCSB], [https://www.ebi.ac.uk/pdbsum/3shj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3shj ProSAT]</span></td></tr> |
| - | [[3shj]] is a | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSB6_YEAST PSB6_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | ||
==See Also== | ==See Also== | ||
| - | *[[Proteasome|Proteasome]] | + | *[[Proteasome 3D structures|Proteasome 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: Saccharomyces cerevisiae]] | + | [[Category: Arciniega M]] |
| - | [[Category: Arciniega | + | [[Category: Beck P]] |
| - | [[Category: Beck | + | [[Category: Gallastegui N]] |
| - | [[Category: Gallastegui | + | [[Category: Groll M]] |
| - | [[Category: Groll | + | [[Category: Hillebrand S]] |
| - | [[Category: Hillebrand | + | [[Category: Huber R]] |
| - | [[Category: Huber | + | |
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Current revision
Proteasome in complex with hydroxyurea derivative HU10
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