3rv8

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[[Image:3rv8.png|left|200px]]
 
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{{STRUCTURE_3rv8| PDB=3rv8 | SCENE= }}
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==Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group==
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<StructureSection load='3rv8' size='340' side='right'caption='[[3rv8]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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===Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rv8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RV8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22607697}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RVC:3-{[(Z)-1-CARBOXY-2-CYCLOPROPYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>RVC</scene>, <scene name='pdbligand=VCE:3-{[(E)-1-CARBOXY-2-CYCLOPROPYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>VCE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rv8 OCA], [https://pdbe.org/3rv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rv8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rv8 ProSAT]</span></td></tr>
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[[3rv8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RV8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref>
==See Also==
==See Also==
*[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]]
*[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022607697</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Bulloch, E M.M.]]
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[[Category: Bulloch EMM]]
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[[Category: Chi, G.]]
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[[Category: Chi G]]
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[[Category: Lott, J S.]]
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[[Category: Lott JS]]
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[[Category: Manos-Turvey, A.]]
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[[Category: Manos-Turvey A]]
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[[Category: Payne, R J.]]
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[[Category: Payne RJ]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Chorismate binding]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Salicylate synthase]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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Current revision

Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group

PDB ID 3rv8

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