4hrv
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4hrv is ON HOLD Authors: Lin, Z., Cai, X., Shen, Y. Description: Crystal Structure of Lipoprotein GNA1162 from Neisseria meningitidis) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Lipoprotein GNA1162 from Neisseria meningitidis== | |
| + | <StructureSection load='4hrv' size='340' side='right'caption='[[4hrv]], [[Resolution|resolution]] 1.89Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4hrv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HRV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hrv OCA], [https://pdbe.org/4hrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hrv RCSB], [https://www.ebi.ac.uk/pdbsum/4hrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hrv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q7BMM3_NEIME Q7BMM3_NEIME] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | GNA1162, a predicted lipoprotein from Neisseria meningitidis, is a potential candidate for a universal vaccine against meningococcal disease caused by N. meningitidis serogroup B. Here, the crystal structure of GNA1162 at 1.89 A resolution determined by single-wavelength anomalous dispersion (SAD) is reported. The structure of GNA1162 appears to be a dimer in the crystallographic asymmetric unit as well as in solution. The overall structure of the dimer indicates that each monomer inserts its C-terminal alpha5 helix into the hydrophobic groove of the other molecule. Moreover, the beta4 strands of each monomer lie antiparallel to each other and interact through multiple main-chain hydrogen bonds. Through structural comparisons and operon predictions, it is hypothesized that GNA1162 is part of a transport system and assists in transport and reassembly. The crystal structure of GNA1162 sheds light on its possible function and provides potentially valuable information for the design of a vaccine against meningococcal disease. | ||
| - | + | Structure of Neisseria meningitidis lipoprotein GNA1162.,Cai X, Lu J, Wu Z, Yang C, Xu H, Lin Z, Shen Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):362-8. doi:, 10.1107/S1744309113004417. Epub 2013 Mar 28. PMID:23545639<ref>PMID:23545639</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4hrv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Neisseria meningitidis]] | ||
| + | [[Category: Cai X]] | ||
| + | [[Category: Lin Z]] | ||
| + | [[Category: Shen Y]] | ||
Current revision
Crystal Structure of Lipoprotein GNA1162 from Neisseria meningitidis
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