1nn8

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[[Image:1nn8.png|left|200px]]
 
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{{STRUCTURE_1nn8| PDB=1nn8 | SCENE= }}
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==CryoEM structure of poliovirus receptor bound to poliovirus==
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<SX load='1nn8' size='340' side='right' viewer='molstar' caption='[[1nn8]], [[Resolution|resolution]] 15.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nn8]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_poliovirus_1_Mahoney Human poliovirus 1 Mahoney]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NN8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nn8 OCA], [https://pdbe.org/1nn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nn8 RCSB], [https://www.ebi.ac.uk/pdbsum/1nn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nn8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nn8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nn8 ConSurf].
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<div style="clear:both"></div>
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===CryoEM structure of poliovirus receptor bound to poliovirus===
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==See Also==
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*[[Art:Polio: A resolution to eradicate|Art:Polio: A resolution to eradicate]]
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{{ABSTRACT_PUBMED_12663789}}
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1nn8]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_poliovirus_1_mahoney Human poliovirus 1 mahoney]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NN8 OCA].
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__TOC__
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</SX>
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==Reference==
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<ref group="xtra">PMID:012663789</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Human poliovirus 1 mahoney]]
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[[Category: Human poliovirus 1 Mahoney]]
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[[Category: Bator, C M.]]
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[[Category: Large Structures]]
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[[Category: Bowman, V D.]]
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[[Category: Bator CM]]
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[[Category: Chipman, P R.]]
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[[Category: Bowman VD]]
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[[Category: He, Y.]]
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[[Category: Chipman PR]]
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[[Category: Kuhn, R J.]]
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[[Category: He Y]]
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[[Category: Mueller, S.]]
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[[Category: Kuhn RJ]]
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[[Category: Mukhopadhyay, S.]]
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[[Category: Mueller S]]
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[[Category: Peng, X.]]
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[[Category: Mukhopadhyay S]]
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[[Category: Rossmann, M G.]]
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[[Category: Peng X]]
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[[Category: Wimmer, E.]]
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[[Category: Rossmann MG]]
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[[Category: Icosahedral virus]]
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[[Category: Wimmer E]]
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[[Category: Picornavirus]]
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[[Category: Virus-receptor complex]]
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Current revision

CryoEM structure of poliovirus receptor bound to poliovirus

1nn8, resolution 15.00Å

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OCA

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