2vyi

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[[Image:2vyi.png|left|200px]]
 
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{{STRUCTURE_2vyi| PDB=2vyi | SCENE= }}
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==Crystal Structure of the TPR domain of Human SGT==
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<StructureSection load='2vyi' size='340' side='right'caption='[[2vyi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vyi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VYI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vyi OCA], [https://pdbe.org/2vyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vyi RCSB], [https://www.ebi.ac.uk/pdbsum/2vyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vyi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SGTA_HUMAN SGTA_HUMAN] Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.<ref>PMID:18759457</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/2vyi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vyi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The small glutamine-rich tetratricopeptide repeat protein (SGT) belongs to a family of cochaperones that interacts with both Hsp70 and Hsp90 via the so-called TPR domain. Here, we present the crystal structure of the TPR domain of human SGT (SGT-TPR), which shows that it contains typical features found in the structures of other TPR domains. Previous studies show that full-length SGT can bind to both Vpu and Gag of human immunodeficiency virus type 1 (HIV-1) and the overexpression of SGT in cells reduces the efficiency of HIV-1 particle release. We show that SGT-TPR can bind Vpu and reduce the amount of HIV-1 p24, which is the viral capsid, secreted from cells transfected with the HIV-1 proviral construct, albeit at a lower efficiency than full-length SGT. This indicates that the TPR domain of SGT is sufficient for the inhibition of HIV-1 particle release but the N- and/or C-terminus also have some contributions. The SGT binding site in Vpu was also identified by using peptide array and confirmed by GST pull-down assay.
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===CRYSTAL STRUCTURE OF THE TPR DOMAIN OF HUMAN SGT===
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Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1.,Dutta S, Tan YJ Biochemistry. 2008 Sep 23;47(38):10123-31. Epub 2008 Aug 30. PMID:18759457<ref>PMID:18759457</ref>
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{{ABSTRACT_PUBMED_18759457}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vyi" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2vyi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYI OCA].
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*[[Small glutamine-rich tetratricopeptide repeat containing protein alpha|Small glutamine-rich tetratricopeptide repeat containing protein alpha]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018759457</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dutta, S.]]
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[[Category: Large Structures]]
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[[Category: Tan, Y J.]]
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[[Category: Dutta S]]
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[[Category: Chaperone]]
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[[Category: Tan YJ]]
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[[Category: Host-virus interaction]]
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[[Category: Phosphoprotein]]
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[[Category: Sgt]]
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[[Category: Tetratricopeptide repeat protein]]
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[[Category: Tpr repeat]]
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Current revision

Crystal Structure of the TPR domain of Human SGT

PDB ID 2vyi

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OCA

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