1tee

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[[Image:1tee.png|left|200px]]
 
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{{STRUCTURE_1tee| PDB=1tee | SCENE= }}
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==Crystal structure of C205F mutant of PKS18 from Mycobacterium tuberculosis==
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<StructureSection load='1tee' size='340' side='right'caption='[[1tee]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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===Crystal structure of C205F mutant of PKS18 from Mycobacterium tuberculosis===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tee]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TEE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15286723}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tee OCA], [https://pdbe.org/1tee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tee RCSB], [https://www.ebi.ac.uk/pdbsum/1tee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tee ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1tee]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEE OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PKS18_MYCTU PKS18_MYCTU] Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.<ref>PMID:12941968</ref> <ref>PMID:15286723</ref> <ref>PMID:15984864</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:015286723</ref><ref group="xtra">PMID:015039574</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Mycobacterium tuberculosis h37rv]]
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Check<jmol>
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[[Category: Naringenin-chalcone synthase]]
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<jmolCheckbox>
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[[Category: Rukmini, R.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/te/1tee_consurf.spt"</scriptWhenChecked>
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[[Category: Sankaranarayanan, R.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Shanmugam, V M.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Substrate binding tunnel]]
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</jmolCheckbox>
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[[Category: Thiolase fold]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tee ConSurf].
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[[Category: Transferase]]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Rukmini R]]
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[[Category: Sankaranarayanan R]]
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[[Category: Shanmugam VM]]

Current revision

Crystal structure of C205F mutant of PKS18 from Mycobacterium tuberculosis

PDB ID 1tee

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