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3unf
From Proteopedia
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| - | {{Large structure}} | ||
| - | {{STRUCTURE_3unf| PDB=3unf | SCENE= }} | ||
| - | ===Mouse 20S immunoproteasome in complex with PR-957=== | ||
| - | {{ABSTRACT_PUBMED_22341445}} | ||
| - | == | + | ==Mouse 20S immunoproteasome in complex with PR-957== |
| - | [[3unf]] is a | + | <StructureSection load='3unf' size='340' side='right'caption='[[3unf]], [[Resolution|resolution]] 2.90Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3unf]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The October 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Proteasome'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_10 10.2210/rcsb_pdb/mom_2013_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UNF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=04C:1,2,4-TRIDEOXY-4-METHYL-2-{[N-(MORPHOLIN-4-YLACETYL)-L-ALANYL-O-METHYL-L-TYROSYL]AMINO}-1-PHENYL-D-XYLITOL'>04C</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3unf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3unf OCA], [https://pdbe.org/3unf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3unf RCSB], [https://www.ebi.ac.uk/pdbsum/3unf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3unf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSA2_MOUSE PSA2_MOUSE] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. | ||
==See Also== | ==See Also== | ||
| - | *[[Proteasome|Proteasome]] | + | *[[Proteasome 3D structures|Proteasome 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Basler, M.]] | ||
| - | [[Category: Groettrup, M.]] | ||
| - | [[Category: Groll, M.]] | ||
| - | [[Category: Heinemeyer, W.]] | ||
| - | [[Category: Huber, E.]] | ||
| - | [[Category: Kirk, C.]] | ||
| - | [[Category: Schwab, R.]] | ||
| - | [[Category: Antigen presentation]] | ||
| - | [[Category: Drug development]] | ||
| - | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Proteasome]] | [[Category: Proteasome]] | ||
| - | [[Category: | + | [[Category: RCSB PDB Molecule of the Month]] |
| + | [[Category: Basler M]] | ||
| + | [[Category: Groettrup M]] | ||
| + | [[Category: Groll M]] | ||
| + | [[Category: Heinemeyer W]] | ||
| + | [[Category: Huber E]] | ||
| + | [[Category: Kirk C]] | ||
| + | [[Category: Schwab R]] | ||
Current revision
Mouse 20S immunoproteasome in complex with PR-957
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