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| - | {{STRUCTURE_1mwp| PDB=1mwp | SIZE=400| SCENE= |right| CAPTION=Human amyloid precursor protein heparin-binding domain [[1mwp]] }}
| + | <StructureSection load='1mwp' size='350' side='right' scene='45/455464/Cv/1' caption='Human amyloid precursor protein heparin-binding domain [[1mwp]]'> |
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| - | '''Amyloid precursor protein''' (APP) is thought to regulate transcription. APP is cleaved by β-secretase and the resulting N terminal peptide which is ca. 40 amino acid long is called hAPP β-peptide. The aggregation of the hAPP β-peptide is the cause of Alzheimer’s Disease. For detailed discussion see<br />
| + | == Function == |
| - | * [[Human APP]]<br />
| + | |
| - | * [[Human APP Intracellular Domain Complex with Fe65-PTB2]]<br />
| + | |
| - | * [[Amyloid beta]].
| + | |
| | | | |
| - | __NOTOC__
| + | '''Amyloid precursor protein''' (APP) is a transmembranal protein which is thought to regulate transcription. APP plays a role in synaptic formation and repair.<ref>PMID:12927332</ref> |
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| - | ==3D structures of amyloid precursor protein== | + | == Disease == |
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| + | APP is cleaved by β-secretase and the resulting N terminal peptide which is ca. 40 amino acid long is called hAPP β-peptide. The aggregation of the hAPP β-peptide is the cause of Alzheimer’s Disease. For detailed discussion see<br /> |
| | + | * [[Human APP]]<br /> |
| | + | * [[Human APP Intracellular Domain Complex with Fe65-PTB2]]<br /> |
| | + | * [[Beta Amyloid forms Plaques]]<br /> |
| | + | * [[Amyloid beta]] |
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| - | [[3nyj]], [[3nyl]], [[3umh]], [[3umi]], [[3umk]] – hAPP E2 domain – human<BR />
| + | == Structural highlights == |
| - | [[3ktm]] – hAPP residues 18-190<BR />
| + | |
| - | [[1ze7]], [[2bp4]] – hAPP zinc-binding domain – NMR<BR />
| + | |
| - | [[2fjz]], [[2fma]] - hAPP residues 133-189<BR />
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| - | [[1owt]] - hAPP residues 133-189 - NMR<BR />
| + | |
| - | [[1rw6]] - hAPP residues 346-551<BR />
| + | |
| - | [[1tkn]] - hAPP residues 460-569 - NMR<BR />
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| - | [[1qyt]], [[1qwp]], [[1qxc]] - hAPP residues 25-35 – NMR<BR />
| + | |
| - | [[1mwp]] - hAPP heparin-binding domain<br />
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| | | | |
| - | ===hAPP β-peptide===
| + | The extracellular region of APP contains several domains named E1 (residues 1-189) and E2 (residues 346-551). The E1 domain contains a growth factor-like or heparin-binding (residues 28-123) and Cu-binding (residues 124-189) subdomains. Additional domains are: Kunitz-type protease inhibitor (residues 287-344) and Zn-binding (residues 672-687). The Z-binding domain is involved in the oligomerizatin of APP. |
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| - | [[1z0q]], [[2beg]] – hAPP β-peptide residues 1-42 – NMR<br />
| + | ==3D structures of amyloid precursor protein== |
| - | [[1amb]], [[1amc]] – hAPP β-peptide residues 1-28 – NMR<br />
| + | [[Amyloid precursor protein 3D structures]] |
| - | [[1qcm]], [[1qwp]], [[1qxc]], [[1qyt]] – hAPP β-peptide residues 25-35 – NMR<br />
| + | |
| - | [[1ba4]], [[1ba6]], [[2lnq]] – hAPP β-peptide residues 1-40 – NMR<br />
| + | |
| - | [[1bjb]], [[1bjc]] – hAPP β-peptide residues 1-28 (mutant) – NMR<br />
| + | |
| - | [[1nmj]] – APP β-peptide residues 1-28 – rat – NMR<br />
| + | |
| - | [[3bae]] – hAPP β-peptide residues 1-28 + antibody<br />
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| - | [[3bkj]] – hAPP β-peptide residues 1-16 + antibody<br />
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| - | [[2roz]] – hAPP β-peptide residues 1-32 + amyloid β A4 precursor protein - NMR<br />
| + | |
| - | [[2wk3]] – hAPP β-peptide residues 1-42 + insulin-degrading enzyme<br /> | + | |
| - | | + | |
| - | ===Amyloid precursor protein binary complex===
| + | |
| | | | |
| - | [[1ze9]] - hAPP zinc-binding domain + Zn – NMR<BR />
| + | </StructureSection> |
| - | [[2fk1]], [[2fk2]], [[2fk3]], [[2fkl]] - hAPP residues 133-189 + Cu<BR />
| + | |
| - | [[3jti]], [[3gci]] – hAPP peptide + phospholipase A2<BR />
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| - | [[3l81]] - hAPP peptide + AP-4 complex subunit μ-1<BR />
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| - | [[3ifl]], [[3ifn]], [[3ifo]], [[3ifp]], [[2r0w]] - hAPP peptide + antibody<BR />
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| - | [[2wk3]] - hAPP residues 1-42 + insulin degrading enzyme<BR />
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| - | [[3dxc]] - hAPP residues 739-770 + Fe65-PTB2<BR />
| + | |
| - | [[3dxd]], [[3dxe]] - hAPP residues 739-770 (mutant) + Fe65-PTB2<BR />
| + | |
| - | [[2roz]] - hAPP peptide + Fe65 C terminal<BR />
| + | |
| - | [[2otk]] - hAPP residues 672-711 + ZAB3 affibody dimer - NMR<BR />
| + | |
| - | [[3l3t]] - hAPP residues 211-267 + mesotrypsin<br />
| + | |
| - | [[3l33]] - hAPP residues 290-341 + trypsin-3 (mutant)
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| | + | == References == |
| | + | <references/> |
| | [[Category:Topic Page]] | | [[Category:Topic Page]] |
