Platelet glycoprotein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:38, 21 July 2024) (edit) (undo)
 
(27 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1m10complexsurf.png|left|350px]]
+
<StructureSection load='' size='350' side='right' scene='1m10/Surface/2' caption='Platelet-receptor glycoprotein Ib alpha (blue) involved in Willebrand disease bound to the von Willebrand Factor A1 Domain (green surface), ([[1m10]])' >
-
 
+
-
<!--
+
-
The line below this paragraph, containing "STRUCTURE_1m10", creates the "Structure Box" on the page.
+
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
-
or leave the SCENE parameter empty for the default display.
+
-
-->
+
-
{{Template:1m10SURFACEapplet}}
+
-
{{STRUCTURE_1m10| PDB=1m10 | SCENE= }}
+
 +
{{Clear}}
===Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain===
===Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain===
- 
-
<!--
 
-
The line below this paragraph, {{ABSTRACT_PUBMED_12183630}}, adds the Publication Abstract to the page
 
-
(as it appears on PubMed at http://www.pubmed.gov), where 12183630 is the PubMed ID number.
 
-
-->
 
{{ABSTRACT_PUBMED_12183630}}
{{ABSTRACT_PUBMED_12183630}}
 +
*'''Platelet glycoprotein Ib alpha''' has a role in the adhesion and migration of leukocytes on vascular thrombus<ref>PMID:10899906</ref>.
 +
*'''Platelet glycoprotein 4''' or '''CD36''' functions as a receptor for thrombospondin and collagen <ref>PMID:2665870</ref>.
 +
*'''Platelet glycoprotein 6''' ha a role in collagen-induced platelet activation<ref>PMID:15381385</ref>.
==Disease==
==Disease==
Line 23: Line 13:
==About this Structure==
==About this Structure==
 +
{{Button ColorLeucine}} <scene name='1m10/Surface/2'>Initial scene</scene>
 +
[[1m10]] is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M10 OCA].
[[1m10]] is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M10 OCA].
-
==3D structures of platelet glycoprotein Ib==
+
</StructureSection>
 +
==3D structures of platelet glycoprotein==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
[[1m0z]] – hPGIb von Willenbrand factor binding domain (mutant) – human <BR />
+
*Platelet glycoprotein Ib
-
[[1gwb]], [[1p9a]], [[1qyy]] – hPGIb N terminal domain <BR />
+
-
'''Platelet glycoprotein Ib complexes'''
+
**[[1gwb]], [[1p9a]], [[1qyy]] – hPGIb von Willenbrand factor binding domain 17-306 - human <BR />
 +
**[[1m0z]] – hPGIb von Willenbrand factor binding domain (mutant) <BR />
 +
**[[3rfe]] – hPGIb b chain 26-146<BR />
 +
**[[3rfe]] – hPGIb b chain 26-146 (mutant)<BR />
 +
**[[6ejx]] – PGIb a chain von Willenbrand factor binding domain - mouse<BR />
-
[[1m10]], [[1sq0]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain (mutant)<BR />
+
*Platelet glycoprotein Ib complexes
-
[[1u0n]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain + botrocetin<BR />
+
-
[[1gwb]] – hPGIb N terminal domain (mutant) + α thrombin <BR
+
-
/>
+
-
[[1p8v]] – hPGIb von Willenbrand factor binding domain (mutant) + prothrombin<BR />
+
-
[[3pmh]] – hPGIb von Willenbrand factor binding domain (mutant) + thrombin<BR />
+
-
[[2bp3]] – hPGIb cytoplasmic domain + filamin A rod domain <BR />
+
-
[[1sq0]] – hPGIb von Willenbrand factor binding domain + peptide inhibitor<BR />
+
 +
**[[1m10]], [[1sq0]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain (mutant)<BR />
 +
**[[6xfq]] – hPGIb von Willenbrand factor binding domain + agkisacucetin<BR />
 +
**[[1u0n]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain + botrocetin<BR />
 +
**[[3pmh]], [[1gwb]] – hPGIb von Willenbrand factor binding domain (mutant) + thrombin<BR />
 +
**[[1p8v]] – hPGIb von Willenbrand factor binding domain (mutant) + prothrombin<BR />
 +
**[[1sq0]] – hPGIb von Willenbrand factor binding domain + peptide inhibitor<BR />
 +
**[[2bp3]] – hPGIb cytoplasmic domain + filamin A rod domain <BR />
 +
**[[1ook]] – hPGIb a chain + alpha thrombin + peptide<BR />
 +
**[[4c2a]], [[4c2b]] – hPGIb a chain (mutant) + von Willenbrand factor <BR />
 +
**[[3p72]] – hPGIb a chain + peptide inhibitor<BR />
 +
 +
*Platelet glycoprotein 4
 +
 +
**[[5lgd]] – hPG4 + PFEMP1 <BR />
 +
 +
*Platelet glycoprotein 6
 +
 +
**[[2gi7]], [5ou7]] – hPG6 <BR />
 +
**[[5ou9]], [[5ou8]] – hPG6 + collagen peptide <BR />
 +
**[[7nmu]] – hPG6 + nanobody <BR />
 +
**[[7r58]] – hPG6 + antibody <BR />
 +
}}
==Reference==
==Reference==
<ref group="xtra">PMID:12183630</ref><references group="xtra"/>
<ref group="xtra">PMID:12183630</ref><references group="xtra"/>
-
 
+
<references/>
==See Also==
==See Also==
*[[Leucine-rich repeat]]
*[[Leucine-rich repeat]]
-
*[[Variable Lymphocyte Receptors]]
+
*[[Variable lymphocyte receptor]]
*[[Lamprey Variable Lymphocyte Receptor]]
*[[Lamprey Variable Lymphocyte Receptor]]
-
*[[Disease]]
+
*[[Diseases]]
[[Category:Topic Page]]
[[Category:Topic Page]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Current revision

Platelet-receptor glycoprotein Ib alpha (blue) involved in Willebrand disease bound to the von Willebrand Factor A1 Domain (green surface), (1m10)

Drag the structure with the mouse to rotate

3D structures of platelet glycoprotein

Updated on 21-July-2024

Reference

  • Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630 doi:10.1126/science.107355
  1. ↑ Simon DI, Chen Z, Xu H, Li CQ, Dong Jf, McIntire LV, Ballantyne CM, Zhang L, Furman MI, Berndt MC, López JA. Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med. 2000 Jul 17;192(2):193-204. PMID:10899906 doi:10.1084/jem.192.2.193
  2. ↑ Kunicki TJ. Platelet membrane glycoproteins and their function: an overview. Blut. 1989 Jul;59(1):30-4. PMID:2665870
  3. ↑ Moroi M, Jung SM. Platelet glycoprotein VI: its structure and function. Thromb Res. 2004;114(4):221-33. PMID:15381385 doi:10.1016/j.thromres.2004.06.046

See Also

Retrieved from "http://52.214.119.220/wiki/index.php/Platelet_glycoprotein"
Personal tools