4k7e

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{{STRUCTURE_4k7e| PDB=4k7e | SCENE= }}
 
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===Crystal structure of Junin virus nucleoprotein===
 
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{{ABSTRACT_PUBMED_23884367}}
 
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==Function==
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==Crystal structure of Junin virus nucleoprotein==
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[[http://www.uniprot.org/uniprot/Q6IVU2_JUNIN Q6IVU2_JUNIN]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses (By similarity).[PIRNR:PIRNR004029]
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<StructureSection load='4k7e' size='340' side='right'caption='[[4k7e]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4k7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Argentinian_mammarenavirus Argentinian mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K7E FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7e OCA], [https://pdbe.org/4k7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k7e RCSB], [https://www.ebi.ac.uk/pdbsum/4k7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6IVU2_JUNIN Q6IVU2_JUNIN] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses (By similarity).[PIRNR:PIRNR004029]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Junin virus (JUNV) is identified as the etiological agent of Argentine hemorrhagic fever (AHF), which leads to a serious public health problem with approximately five million people at risk. It is treated as a potential bioterrorism agent for its rapid transmission by aerosols. JUNV is a negative-sense single-stranded RNA (-ssRNA) virus that belongs to the genus Arenavirus within the family Arenaviridae and its genomic RNA contains two segments encoding four proteins. Among these proteins, the nucleoprotein (NP) has essential roles in viral RNA synthesis and immune suppression, but the molecular mechanisms are only partially understood. Here, we represent a 2.2 A crystal structure of the C-terminal domain of JUNV NP. This structure shows high similarity with the Lassa fever virus (LASV) NP C-terminal domain. However, both the structure and function show differences compare to the LASV NP. This study extends our structural insight into the -ssRNA virus nucleoproteins.
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==About this Structure==
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Crystal structure of Junin virus nucleoprotein.,Zhang Y, Li L, Liu X, Dong S, Wang W, Huo T, Guo Y, Rao Z, Yang C J Gen Virol. 2013 Jul 24. PMID:23884367<ref>PMID:23884367</ref>
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[[4k7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Junin_virus Junin virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7E OCA].
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==See Also==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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*[[Nucleoprotein|Nucleoprotein]]
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</div>
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<div class="pdbe-citations 4k7e" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:023884367</ref><references group="xtra"/><references/>
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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[[Category: Junin virus]]
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== References ==
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[[Category: Dong, S S.]]
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<references/>
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[[Category: Huo, T.]]
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__TOC__
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[[Category: Li, L.]]
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</StructureSection>
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[[Category: Liu, X.]]
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[[Category: Argentinian mammarenavirus]]
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[[Category: Rao, Z H.]]
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[[Category: Large Structures]]
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[[Category: Wang, W M.]]
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[[Category: Dong SS]]
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[[Category: Yang, C.]]
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[[Category: Huo T]]
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[[Category: Zhang, Y J.]]
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[[Category: Li L]]
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[[Category: Alpha/beta/alpha sandwich]]
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[[Category: Liu X]]
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[[Category: Nucleoprotein]]
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[[Category: Rao ZH]]
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[[Category: Viral protein]]
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[[Category: Wang WM]]
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[[Category: Yang C]]
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[[Category: Zhang YJ]]

Current revision

Crystal structure of Junin virus nucleoprotein

PDB ID 4k7e

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