1x18

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{{STRUCTURE_1x18| PDB=1x18 | SCENE= }}
 
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===Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT===
 
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{{ABSTRACT_PUBMED_15866174}}
 
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==Function==
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==Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT==
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[[http://www.uniprot.org/uniprot/RS7_THET8 RS7_THET8]] One of the primary rRNA binding proteins, it binds directly to 3'-end of the 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center. Binds mRNA and the E site tRNA blocking its exit path in the ribosome. This blockage implies that this section of the ribosome must be able to move to release the deacetylated tRNA.[HAMAP-Rule:MF_00480_B] [[http://www.uniprot.org/uniprot/RS11_THET8 RS11_THET8]] Located on the upper part of the platform of the 30S subunit, where it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome, where it interacts both with the Shine-Dalgarno helix and mRNA.[HAMAP-Rule:MF_01310] [[http://www.uniprot.org/uniprot/RS18_THETH RS18_THETH]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS2_THET8 RS2_THET8]] Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B]
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<SX load='1x18' size='340' side='right' viewer='molstar' caption='[[1x18]], [[Resolution|resolution]] 13.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1x18]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X18 FirstGlance]. <br>
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[[1x18]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X18 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 13.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x18 OCA], [https://pdbe.org/1x18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x18 RCSB], [https://www.ebi.ac.uk/pdbsum/1x18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x18 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RS2_THET8 RS2_THET8] Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/1x18_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x18 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[GTP-binding protein|GTP-binding protein]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
*[[Ribosomal protein S11|Ribosomal protein S11]]
*[[Ribosomal protein S11|Ribosomal protein S11]]
*[[Ribosomal protein S18|Ribosomal protein S18]]
*[[Ribosomal protein S18|Ribosomal protein S18]]
*[[Ribosomal protein S2|Ribosomal protein S2]]
*[[Ribosomal protein S2|Ribosomal protein S2]]
*[[Ribosomal protein S7|Ribosomal protein S7]]
*[[Ribosomal protein S7|Ribosomal protein S7]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015866174</ref><references group="xtra"/><references/>
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</SX>
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[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Agrawal, R K.]]
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[[Category: Agrawal RK]]
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[[Category: Barat, C.]]
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[[Category: Barat C]]
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[[Category: Sharma, M R.]]
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[[Category: Sharma MR]]
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[[Category: Contact sites of era protein on the 30s ribosomal subunit]]
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[[Category: Structural protein-rna complex]]
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Current revision

Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT

1x18, resolution 13.50Å

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OCA

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