4mr0

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{{STRUCTURE_4mr0| PDB=4mr0 | SCENE= }}
 
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===Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae===
 
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{{ABSTRACT_PUBMED_24321492}}
 
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==Function==
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==Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae==
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[[http://www.uniprot.org/uniprot/PFBA_STRR6 PFBA_STRR6]] Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.
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<StructureSection load='4mr0' size='340' side='right'caption='[[4mr0]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4mr0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MR0 FirstGlance]. <br>
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[[4mr0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR0 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mr0 OCA], [https://pdbe.org/4mr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mr0 RCSB], [https://www.ebi.ac.uk/pdbsum/4mr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mr0 ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024321492</ref><references group="xtra"/><references/>
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</table>
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[[Category: Beulin, D S.J.]]
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== Function ==
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[[Category: Ponnuraj, K.]]
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[https://www.uniprot.org/uniprot/PFBA_STRR6 PFBA_STRR6] Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.
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[[Category: Adhesion]]
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__TOC__
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[[Category: Cell adhesion]]
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</StructureSection>
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[[Category: Fibronectin]]
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[[Category: Large Structures]]
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[[Category: Plasimin and fibronectin-binding protein]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Plasminogen]]
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[[Category: Beulin DSJ]]
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[[Category: Surface protein]]
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[[Category: Ponnuraj K]]

Current revision

Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae

PDB ID 4mr0

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