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4ip8

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{{STRUCTURE_4ip8| PDB=4ip8 | SCENE= }}
 
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===Structure of human serum amyloid A1===
 
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==Disease==
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==Structure of human serum amyloid A1==
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[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.
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<StructureSection load='4ip8' size='340' side='right'caption='[[4ip8]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4ip8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IP8 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Major acute phase reactant. Apolipoprotein of the HDL complex.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.193&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ip8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip8 OCA], [https://pdbe.org/4ip8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ip8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ip8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ip8 ProSAT]</span></td></tr>
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[[4ip8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP8 OCA].
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</table>
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[[Category: Lu, J.]]
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== Disease ==
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[[Category: Sun, P D]]
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[https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.
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[[Category: Four-helix bundle]]
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== Function ==
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[[Category: Human serum]]
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[https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Major acute phase reactant. Apolipoprotein of the HDL complex.
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[[Category: Main constituent of secondary amyloid]]
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__TOC__
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[[Category: Protein binding]]
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</StructureSection>
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[[Category: Secondary amyloid]]
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[[Category: Homo sapiens]]
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[[Category: Toll like receptor]]
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[[Category: Large Structures]]
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[[Category: Lu J]]
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[[Category: Sun PD]]

Current revision

Structure of human serum amyloid A1

PDB ID 4ip8

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