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4hnp

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==Crystal structure of yeast 20S proteasome in complex with vinylketone carmaphycin analogue VNK1==
==Crystal structure of yeast 20S proteasome in complex with vinylketone carmaphycin analogue VNK1==
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<StructureSection load='4hnp' size='340' side='right' caption='[[4hnp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='4hnp' size='340' side='right'caption='[[4hnp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hnp]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HNP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hnp]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HNP FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ONK:N-HEXANOYL-L-VALYL-N~1~-[(3S,4S)-3-HYDROXY-2,6-DIMETHYLHEPT-1-EN-4-YL]-N~5~,N~5~-DIMETHYL-L-GLUTAMAMIDE'>ONK</scene>, <scene name='pdbligand=VNK:N-HEXANOYL-L-VALYL-N~1~-[(3S,4S)-3-HYDROXY-2,6-DIMETHYLHEPTAN-4-YL]-N~5~,N~5~-DIMETHYL-L-GLUTAMAMIDE'>VNK</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ONK:N-HEXANOYL-L-VALYL-N~1~-[(3S,4S)-3-HYDROXY-2,6-DIMETHYLHEPT-1-EN-4-YL]-N~5~,N~5~-DIMETHYL-L-GLUTAMAMIDE'>ONK</scene>, <scene name='pdbligand=VNK:N-HEXANOYL-L-VALYL-N~1~-[(3S,4S)-3-HYDROXY-2,6-DIMETHYLHEPTAN-4-YL]-N~5~,N~5~-DIMETHYL-L-GLUTAMAMIDE'>VNK</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hrc|4hrc]], [[4hrd|4hrd]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnp OCA], [https://pdbe.org/4hnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hnp RCSB], [https://www.ebi.ac.uk/pdbsum/4hnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hnp ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hnp RCSB], [http://www.ebi.ac.uk/pdbsum/4hnp PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4hnp" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Proteasome|Proteasome]]
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*[[Proteasome 3D structures|Proteasome 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Groll M]]
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[[Category: Groll, M.]]
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[[Category: Stein M]]
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[[Category: Stein, M.]]
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[[Category: Trivella DBB]]
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[[Category: Trivella, D B.B.]]
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[[Category: Carmaphycin]]
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[[Category: Epoxyketone]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Proteasome]]
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[[Category: Vinylketone]]
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Current revision

Crystal structure of yeast 20S proteasome in complex with vinylketone carmaphycin analogue VNK1

PDB ID 4hnp

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